Table 1.

Ideal characteristics of fixed dose combination drugs in hypertension (adapted from Patel et  al)34

Characteristic
High efficacy (blood pressure reduction)
Additive/synergistic blood pressure reduction
Supported by clinical trials
Mitigation of side‐effects of either or both individual agents
Potential for wide availability and affordability
Safe and efficacious in diverse demographic settings (ie, race, ethnicity, sex, geography, salt‐sensitivity)
Daily dosing formulation
Scored tablet with multiple doses which permit split tablet dosing and easy titration