Table 4.

Preferred and acceptable pharmacologic agents (in order of preference) within each drug class

Drug class	Agent	Preference	Characteristics
ARB	Azilsartan	Preferred	Most potent ARB Long duration of action
	Telmisartan	Preferred	Long duration of action
	Irbesartan	Preferred	Long duration of action
	All other long‐acting ARBs (candesartan, valsartan)	Acceptable
	Losartan and olmesartan	Non‐preferred	Losartan—shorter duration of action Olmesartan—association with enteropathy
ACE‐I	Lisinopril, ramipril, benazepril	Preferred	Long duration of action and widely available
	All other long‐acting agents (perindopril, trandolapril, quinapril, fosinopril, ramipril, moexipril)	Acceptable	Long duration of action
	Enalapril and captopril	Non‐preferred	Short duration of action
CCBS	Amlodipine	Preferred	Solid evidence, long duration of action, and widely available
	Other long‐acting, once‐daily dihydropyridines (nifedipine, felodipine, nisoldipine)	Acceptable	Long duration of action
	Non‐dihydropyridines: verapamil and diltiazem	Non‐preferred	Less evidence and more complicated side‐effect profile
Diuretics	Chlorthalidone	Preferred	Long duration of action Supported by evidence Most potent thiazide‐like diuretic
	Hydrochlorothiazide	Acceptable	Shorter duration of action, widely available
	Indapamide	Acceptable	May be more costly, less widely available

ACE‐I, angiotensin‐converting enzyme inhibitors; ARB, angiotensin receptor blockers; CCB, calcium channel blockers.