Figure 2.

Illustration of the addictive synergistic interaction between HTN and HHcy toward CKD and its components. Group 1: non‐HTN and non‐HHcy; Group 2: HTN and non‐HHcy; Group 3: non‐HTN and HHcy; Group 4: HTN and HHcy. In each panel, Group 4 has a significant higher OR for the outcome (CKD, reduced eGFR, or albuminuria), and a considerable portion of the OR in group 4 is caused by the effect of the synergistic interaction. For CKD, the portion is 41.5%; for reduced eGFR, the portion is 44.9%; for albuminuria, the portion is 29.5%. CKD, chronic kidney disease; eGFR, estimated glomerular filtration ratio; ORs, odds ratios