Table 4.
Interaction analysis of HTN and HHcy on the risk of CKD
| CKD | Reduced eGFR | Albuminuria | |
|---|---|---|---|
| Crude model | |||
| Addictive scale | |||
| RERI | 8.090 (5.473, 10.707) | 35.513 (23.875, 47.150) | 2.593 (1.203, 3.984) |
| AP | 0.565 (0.471, 0.658) | 0.665 (0.601, 0.729) | 0.398 (0.236, 0.559) |
| S index | 2.545 (1.991, 3.253) | 3.105 (2.541, 3.793) | 1.886 (1.335, 2.665) |
| Multiplicative scale | |||
| ORs | 1.097 (0.782, 1.539) | 0.622 (0.436, 0.888) | 1.125 (0.732, 1.728) |
| Multivariate adjusted model | |||
| Addictive scale | |||
| RERI | 2.107 (1.071‐3.143) | 4.637 (1.795‐7.479) | 1.018 (0.134‐1.902) |
| AP | 0.415 (0.270‐0.561) | 0.449 (0.254‐0.644) | 0.295 (0.088‐0.502) |
| S index | 2.072 (1.449‐2.962) | 1.988 (1.303‐3.033) | 1.710 (1.071‐2.729) |
| Multiplicative scale | |||
| ORs | 1.342 (0.970‐1.857) | 1.319 (0.817‐2.128) | 1.177 (0.790‐1.754) |
Abbreviations: AP, the attributable proportion due to interaction; BMI, body mass index; CKD, chronic kidney disease; DM, diabetes mellitus; eGFR, estimated glomerular filtration ratio; HDL‐C, high‐density lipoprotein cholesterol; HHcy, hyperhomocysteinemia; HTN, hypertension; PIR, poverty‐to‐income ratio; RERI, the relative excess risk due to interaction; S index, synergy index; TC, total cholesterol; WC, waist circumference.
Crude model: no adjustment; multivariate adjusted model: adjusted by age, sex, race, education level, PIR, physical activity, drinking frequency, current smoking status, TC, HDL‐C, serum folate, vitamin B12, BMI, WC, and DM.