Table 4.
Neuropsychological tests
| Neuropsychological test | Baseline | 1‐y follow‐up | P value, difference mean (95% CI) |
|---|---|---|---|
| Choice reaction time (s), n=46a | 0.56 (0.08) | 0.56 (0.08) |
0.6448, 0.0054 (−0.018 to 0.029) |
| Selective reaction time (s), n=47b | 0.65/0.14 | 0.61/0.12 |
0.0116, −0.036 (−0.062 to −0.009) |
| Rey auditory verbal learning test (no.), n = 46a | 13.5/4.5 | 15/1 |
0.0001, 1.74 (0.924 to 2.55) |
| First recognition (no.), n = 47a | 13/3 | 12/2 |
0.2777, 0.681 (−0.096 to 1.46) |
| Pieron test (%), n = 46a | 92.21 (6.66) | 93.46 (6.64) |
0.1395, 2.52 (−0.266 to 5.32) |
| Trail making test (s), n = 47a | 29.33 (11.21) | 28.47 (9.76) |
0.5721, −0.83 (−3.76 to 2.11) |
| Digit span test (no.: forward + backward), n = 47a | 10/2.5 | 11/3 |
0.0076, 1.23 (0.235 to 2.23) |
| Block design test (s), n = 44a | 25.36 (3.57) | 25.62 (3.72) |
0.4065, 0.545 (−0.767 to 1.86) |
| Digit symbol test (no.), n = 45a | 46.85 (10.95) | 51.5 (10.73) |
<0.0001, 4.2 (2.68 to 5.72) |
| Mean of standardized test scores, n = 47a | 1.98/0.55 | 3.19/0.63 |
<0.0001, 1.23 (1.09 to 1.38) |
| Spielberger state anxiety inventory (score), n = 46a | 40.5/15 | 34/10 |
0.0008, −4.24 (−6.52 to −1.95) |
| Spielberger trait anxiety inventory (score), n = 44a | 38.83 (8.18) | 32.4 (6.66) |
<0.0001, −5.5 (−7.4 to −3.6) |
| Beck depression inventory (score), n = 47a | 4.5/6.5 | 3/6 |
0.1752, 0 (−1.87 to 1.87) |
CI, confidence interval.
a
Paired t test: data expressed as mean (SD).
b
Wilcoxon matched‐pairs signed‐ranks test: data expressed as median/interquartile range.