. 2021 Mar 9;8(3):267–275. doi: 10.4103/2347-5625.311003

Table 2.

The effects of the symptom cluster management intervention based on symptom management theory on outcome measures in comparison to the control group

Symptoms	Times (mean±SD)				Time, P	Group, P	Time × group interaction, P	Effect size Cohen’d

	Baseline^a	Day 7	Day 14	Day 28
Fatigue^b
Experimental	5.03±2.07	4.25±1.60	3.93±1.59**	3.58±1.63**	0.168	<0.001	<0.001*	2.00
Control	4.70±1.99	5.73±1.71**	6.53±1.41**	6.63±1.41**
Loss of appetite^b
Experimental	5.45±2.23	4.50±1.85	4.00±1.85**	3.70±1.67**	0.009	<0.001	<0.001*	1.74
Control	6.35±2.09	6.63±1.82**	6.90±1.81**	6.83±1.92**
Anxiety^b
Experimental	5.88±1.80	4.48±1.78**	3.75±2.01**	3.53±2.06**	<0.001	<0.001	<0.001*	1.69
Control	6.55±1.84	6.83±1.77**	6.88±1.83**	6.82±1.78**

^aBaseline defined as prior to start CTX, ^bScores range from 0 (no symptom) to 10 (worst possible). Post hoc analysis time × group interaction: *Statistically significant difference between groups at <0.05 level, **Bonferroni’s post hoc with P<0.05 compared to baseline. SD: Standard deviation, CTX: Chemotherapy treatment