Table 3.
Mean change at 12 weeks of treatment from baseline in clinic and ambulatory blood pressure and pulse rate in patients with white‐coat or sustained uncontrolled hypertension by randomization
| Variable | Valsartan/amlodipine | Nifedipine GITS | Between‐group difference (95%CI) | P |
|---|---|---|---|---|
| White‐coat uncontrolled hypertension | n = 29 | n = 24 | ||
| Clinic BP, mm Hg | ||||
| Systolic | −16.2 ± 1.9** | −14.8 ± 2.2** | −1.4 (−7.2, 4.4) | 0.63 |
| Diastolic | −4.7 ± 1.7* | −3.7 ± 2.0* | −1.0 (−6.3, 4.2) | 0.69 |
| Clinic pulse rate, beats/min | −2.3 ± 1.8 | −3.9 ± 1.9 | 1.6 (−3.7, 6.8) | 0.55 |
| Ambulatory BP recording | ||||
| 24‐h systolic BP, mm Hg | 1.2 ± 2.3 | −0.1 ± 2.2 | 1.3 (−5.2, 7.8) | 0.69 |
| 24‐h diastolic BP, mm Hg | 1.4 ± 1.6 | 0.6 ± 1.3 | 0.7 (−3.5, 4.9) | 0.74 |
| 24‐h pulse rate, beats/min | −0.5 ± 2.1 | 0.9 ± 2.1 | −1.4 (−7.5, 4.7) | 0.65 |
| Daytime systolic BP, mm Hg | 2.6 ± 2.4 | 0.7 ± 2.9 | 1.9 (−5.6, 9.5) | 0.61 |
| Daytime diastolic BP, mm Hg | 2.8 ± 1.7 | 1.0 ± 1.7 | 1.8 (−3.1, 6.7) | 0.46 |
| Daytime pulse rate, beats/min | −2.1 ± 2.5 | 0.01 ± 2.4 | −2.1 (−9.1, 4.9) | 0.54 |
| Nighttime systolic BP, mm Hg | −2.5 ± 2.9 | 0.9 ± 2.0 | −3.4 (−10.5, 3.6) | 0.33 |
| Nighttime diastolic BP, mm Hg | −0.8 ± 2.2 | 0.8 ± 1.3 | −1.6 (−6.8, 3.5) | 0.52 |
| Nighttime pulse rate, beats/min | 0.6 ± 2.6 | 1.5 ± 2.5 | −0.8 (−8.3, 6.6) | 0.82 |
| Sustained uncontrolled hypertension | n = 46 | n = 51 | ||
| Clinic BP, mm Hg | ||||
| Systolic | −14.4 ± 1.7** | −10.5 ± 1.6** | −3.9 (−8.6, 0.7) | 0.10 |
| Diastolic | −5.9 ± 1.2** | −3.1 ± 1.2* | −2.7 (−6.1, 0.6) | 0.11 |
| Clinic pulse rate, beats/min | −1.7 ± 1.4 | −1.9 ± 1.3 | 0.2 (−3.5, 3.9) | 0.93 |
| Ambulatory BP recording | ||||
| 24‐h systolic BP, mm Hg | −8.5 ± 1.7** | −3.6 ± 1.3* | −4.9 (−9.2, −0.7) | 0.02 |
| 24‐h diastolic BP, mm Hg | −6.6 ± 1.5** | −2.8 ± 1.0* | −3.8 (−7.3, −0.3) | 0.03 |
| 24‐h pulse rate, beats/min | 2.9 ± 1.0* | 0.2 ± 1.1 | 2.6 (−0.4, 5.6) | 0.08 |
| Daytime systolic BP, mm Hg | −7.8 ± 1.8** | −2.9 ± 1.6 | −4.7 (−9.8, −0.3) | 0.045 |
| Daytime diastolic BP, mm Hg | −6.0 ± 1.7** | −2.1 ± 1.3 | −3.9 (−7.7, −0.03) | 0.048 |
| Daytime pulse rate, beats/min | 2.2 ± 1.2 | 0.3 ± 1.3 | 1.9 (−1.6, 5.4) | 0.29 |
| Nighttime systolic BP, mm Hg | −9.9 ± 1.9** | −4.9 ± 1.4* | −5.0 (−9.7, −0.3) | 0.04 |
| Nighttime diastolic BP, mm Hg | −7.9 ± 1.5** | −3.7 ± 1.1* | −4.1 (−7.8, −0.5) | 0.03 |
| Nighttime pulse rate, beats/min | 2.8 ± 1.2* | 0.8 ± 1.3 | 2.0 (−1.5, 5.5) | 0.27 |
Values are least square mean ± standard error, unless otherwise indicated.
BP, blood pressure; CI, confidence interval.
Significance of the difference from baseline,
*
P < 0.05,
**
P < 0.0001.