TABLE 4.
Event Rates for Adverse Cardiovascular Outcomes using ESC HFA-PEFF Score Categories
| Outcomes, n (%) | Asymptomatic N=3749 |
Unexplained Dyspnea, HFA PEFF Score 0–2 N=117 |
Unexplained Dyspnea, HFA PEFF Score 3 N=214 |
Unexplained Dyspnea, HFA PEFF Score 4–6 N=310 |
Known HFpEF N=502 |
|---|---|---|---|---|---|
| Heart failure hospitalization or death | |||||
| • Number of events | 416 | 19 | 36 | 83 | 172 |
| • Event rate (95% CI) per 1000 person-years | 20.7 (31.6, 45.8) | 31.8 (20.3, 49.9) | 32.4 (23.4, 44.9) | 54.3 (43.8, 67.3) | 72.6 (62.6, 84.3) |
| • Hazard ratio (95% CI) | Ref | 1.56 (0.98, 2.47) | 1.58 (1.12, 2.22) | 2.67 (2.11, 3.38) | 3.62 (3.03, 4.32) |
| Heart failure hospitalization | |||||
| • Number of events | 119 | 4 | 10 | 37 | 63 |
| • Event rate (95% CI) per 1000 person-years | 5.9 (5.0, 7.1) | 6.8 (2.5, 18.0) | 9.1 (4.9, 16.9) | 24.3 (17.6, 33.5) | 32.4 (25.3, 41.5) |
| • Hazard ratio (95% CI) | ref | 1.16 (0.43, 3.13) | 1.54 (0.81, 2.94) | 4.17 (2.88, 6.03) | 5.59 (4.12, 7.59) |
| Death | |||||
| • Number of events | 343 | 16 | 29 | 65 | 143 |
| • Event rate (95% CI) per 1000 person-years | 16.9 (15.2, 18.8) | 26.4 (16.2, 43.1) | 25.7 (17.8, 36.9) | 40.8 (32.0, 52.1) | 58.0 (49.2, 68.3) |
| • Hazard ratio (95% CI) | Ref | 1.59 (0.96, 2.62) | 1.54 (1.05, 2.25) | 2.46 (1.88, 3.20) | 3.55 (2.92, 4.32) |
ESC, European Society of Cardiology; CI, confidence interval; HFpEF, heart failure with preserved ejection fraction.