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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: JACC Heart Fail. 2020 Jun 10;8(8):640–653. doi: 10.1016/j.jchf.2020.03.013

TABLE 5.

Event Rates for Adverse Cardiovascular Outcomes using H2FPEF Score Categories

Outcomes, n (%) Asymptomatic
N=3749		 Unexplained Dyspnea, H2FPEF Score <6
N=572		 Unexplained Dyspnea, H2FPEF Score ≥6
N=69		 Known HFpEF
N=502
Heart failure hospitalization or death
 • Number of events 416 111 27 172
 • Event rate (95% CI) per 1000 person-years 20.7 (31.6, 45.8) 38.0 (31.6, 45.8) 84.9 (58.2, 123.7) 72.6 (62.6, 84.3)
 • Hazard ratio (95% CI) ref 1.86 (1.51, 2.29) 4.27 (2.89, 6.31) 3.62 (3.03, 4.32)
Heart failure hospitalization
 • Number of events 119 40 11 63
 • Event rate (95% CI) per 1000 person-years 5.9 (5.0, 7.1) 13.7 (10.1, 18.7) 36.0 (20.0, 65.1) 32.4 (25.3, 41.5)
 • Hazard ratio (95% CI) ref 2.34 (1.64, 3.35) 6.32 (3.40, 11.72) 5.59 (4.12, 7.59)
Death
 • Number of events 343 89 21 143
 • Event rate (95% CI) per 1000 person-years 16.9 (15.2, 18.8) 29.8 (24.2, 36.7) 61.9 (40.4, 94.9) 58.0 (49.2, 68.3)
 • Hazard ratio (95% CI) Ref 1.78 (1.41, 2.25) 3.80 (2.45, 5.91) 3.55 (2.92, 4.32)

CI, confidence interval; HFpEF, heart failure with preserved ejection fraction.