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. 2020 Aug 18;223(7):1284–1294. doi: 10.1093/infdis/jiaa513

Figure 1.

Figure 1.

Amyloid, Aβ peptides, and amylin in cerebrospinal fluid (CSF) of subjects without and with varicella zoster virus (VZV) vasculopathy. A, Compared to CSF from 36 subjects without VZV vasculopathy (VZV–, red circles), CSF from 16 VZV vasculopathy subjects (VZV+, blue squares) had significantly elevated levels of amyloid, significantly decreased levels of Aβ40, insignificant changes in Aβ42, and significantly elevated levels of amylin (**P < .01, ***P < .001). B, Anti-VZV immunoglobulin G (IgG) antibody levels in CSF from VZV+ subjects (blue squares) positively and significantly correlated with levels of amyloid (*P < .05). Conversely, anti-VZV IgG antibody levels in CSF from VZV– subjects (red circles) did not significantly correlate with levels of amyloid (P > .05). C, Amylin is positively correlated with amyloid in VZV+ subjects (blue squares) but no correlation was seen in VZV– subjects (red circles). Difference in regressions approached significance (P = .06). Abbreviations: AU, artificial units; CSF, cerebrospinal fluid; ns, not significant; Thio-T, thioflavin T; VZV, varicella zoster virus.