Figure 5.

Varicella zoster virus (VZV)–induced amylin has a proviral function in quiescent primary adult human perineurial cells (qHPNCs). The qHPNCs were transfected with a scrambled small interfering RNA (siRNA) or 2 designs of siRNA targeting amylin 1 hour prior to VZV infection. At 3 days postinfection, compared to VZV-infected qHPNCs transfected with scrambled siRNA (n = 5), amylin-targeted siRNA design 1 (n = 3) and design 2 (n = 9) significantly reduced VZV transcripts (mean fold change ± standard error of the mean [SEM], 0.4 ± 0.13 and 0.07 ± 0.02, respectively). ***P < .001. Bars represent mean fold change ± SEM.