Table 2.
Incidence and Intensity of Reinfection With Schistosoma japonicum Is Predicted by Antibody Responses to Sj6-8, SjERBP1b, and Sj4-1 Using Generalized Estimating Equation Modelsa
| Outcome and Antibody | Sj6-8 | SjERBP1b | Sj4-1 | |||
|---|---|---|---|---|---|---|
| B or RR (95% CI)b | P Value | B or RR (95% CI)b | P Value | B or RR (95% CI)b | P Value | |
| Intensity of infection, EPG | ||||||
| IgE | –0.097 (–.177 to –.018) | .016 | –0.174 (–.490 to .142) | .28 | –0.350 (–.554 to –.146) | .001 |
| IgG | 0.243 (.067–.419) | .007 | 0.305 (.117–.494) | .001 | 0.014 (–.211 to .239) | .90 |
| IgG1 | 0.063 (–.086 to .212) | .40 | 0.225 (.057–.393) | .009 | –0.364 (–1.016 to .288) | .27 |
| IgG2 | 0.117 (.005–.228) | .040 | 0.160 (.037–.284) | .011 | 0.048 (–.067 to .164) | .41 |
| IgG3 | 0.018 (–.074 to .109) | .71 | 0.083 (–.032 to .198) | .16 | –0.161 (–.275 to –.047) | .006 |
| IgG4 | 0.227 (.130–.324) | <.001 | 0.268 (.169–.368) | <.001 | 0.075 (.007–.144) | .031 |
| Reinfection (yes vs no) | ||||||
| IgE | 0.93 (.86–1.01) | .09 | 0.89 (.63–1.25) | .50 | 0.71 (.58–.86) | <.001 |
| IgG | 1.20 (.99–1.44) | .06 | 1.33 (1.10–1.61) | .003 | 0.92 (.75–1.13) | .42 |
| IgG1 | 1.11 (.98–1.25) | .11 | 1.23 (1.04–1.45) | .015 | 0.68 (.34–1.39) | .29 |
| IgG2 | 1.14 (1.02–1.27) | .020 | 1.21 (1.07–1.36) | .002 | 1.04 (.94–1.15) | .44 |
| IgG3 | 1.02 (.94–1.11) | .62 | 1.11 (.99–1.24) | .06 | .82 (.74–.92) | <.001 |
| IgG4 | 1.23 (1.10–1.38) | <.001 | 1.25 (1.14–1.38) | <.001 | 1.07 (1.00–1.14) | .043 |
Abbreviations: CI, confidence interval; EPG, eggs per gram of stool; IgE, immunoglobulin E; IgG, immunoglobulin G; RR, relative risk.
aAntibody levels and intensity of reinfection were natural log-transformed and generalized estimating equation models were adjusted for sex, socioeconomic status, and Trichuris trichiura and hookworm intensity.
b B is the unstandardized regression coefficients of reinfection intensity.