Table 1.

Amino Acid Alterations and Combinations in the penA Gene of Neisseria gonorrhoeae Strains Associated With the Highest Sensitivity and Specificity for Decreased Susceptibility to Ceftriaxone

	Mosaic penA		Nonmosaic penA		All Strains
penA Alterations	Sensitivity	Specificity	Sensitivity	Specificity	Sensitivity	Specificity
L447V	1	0.008	0.003	0.963	0.447	0.742
A311V	0.092	1	0	0.999	0.039	0.999
I312M	0.98	0.032	0	0.997	0.429	0.781
T483P/S	0.082	1	0	0.997	0.036	0.998
V316T/P	0.962	0.043	0	0.997	0.416	0.793
H541N	0.957	0.017	0.068	0.907	0.464	0.699
F504L	0.957	0.012	1	0.027	0.981	0.023
A510V	0.957	0·012	1	0.027	0.981	0.023
≥1 of G542S, P551L/S, A501V/T	0.032	0.972	0.947	0.450	0.583	0.623
A501V/T	0.007	0.997	0.661	0.919	0.369	0.936
≥1 of G542S, P551L/S, I566V	0.359	0.810	0.953	0.328	0.716	0.487
≥1 of G542S, P551L/S, A574N	0.359	0.582	0.950	0.207	0.723	0.276
≥1 of P551L/S and I566V	0.360	0.582	0.908	0.386	0.690	0.422