Table 2.

Amino Acid Alterations and Combinations in Non-penA Genes of Neisseria gonorrhoeae Strains Associated With the Highest Sensitivity and Specificity for Decreased Susceptibility to Ceftriaxone

	Mosaic penA		Nonmosaic penA		All Strains
Non-penA Alterations	Sensitivity	Specificity	Sensitivity	Specificity	Sensitivity	Specificity
ponA L421P	1	0.108	0.991	0.521	0.996	0.454
mtrR delA	0.954	0.172	0.952	0.609	0.953	0.528
mtrR delA + ponA L421P	0.919	0.239	0.893	0.717	0.906	0.64
≥1 penB G120, A121 alteration(s)	0.988	0.111	0.945	0.486	0.966	0.421
mtrR delA + penB G120 +A121 alteration(s)	0.971	0.38	0.852	0.721	0.918	0.649
penB G120 + A121 alterations	0.984	0.126	0.902	0.607	0.943	0.523
ponA L421P + and ≥1 of penB G120, A121 alteration(s)	0.977	0.127	0.862	0.684	0.922	0.607