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. 2020 Aug 6;223(7):1222–1231. doi: 10.1093/infdis/jiaa482

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© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

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Figure 1. — Adoptive transfer proof of principle with postvaccine pneumococcal serum samples. Prevaccine (Pre) and postvaccine (Post) serum samples were adoptively transferred to mice from human subjects who received the conjugate pneumococcal vaccine and had a high (P1), moderate (P2), or low (P3) vaccine response by opsonophagocytic (OP) titer. Colony-forming units (CFUs) per milliliter were enumerated from whole homogenized kidney (n = 5 mice per group). Mice receiving serum samples from high- and medium-titer vaccine respondents exhibited no detectable Streptococcus pneumoniae 24 hours after infection. Abbreviation: LLD, lower limit of detection.