Fig. 6.

BBD attenuates lung inflammation in mice with acute lung injury. C57BL/6 mice were infected with 200 PFU of influenza A PR/8/34 or vehicle for 5 days before being challenged with Staphylococcus aureus (SA) at the indicated CFU in 50 μL: 5 × 10⁷ for A-B and 2.5 × 10⁷ for C-D. (A) Survival curves; n = 16, model group; n = 17, BBD treatment group. (B) Representative histological sections of lungs at 12 h post SA challenge (n = 4–5 for each group). (C) CFU counts in LH and BAL samples (n = 4–5 for each group). (D) Concentrations of TNF-α and IL-6 in BALF (n = 3–5 for each group). * P < 0.05 vs. model group. CFU, colony-forming units; PFU, plaque-forming units; BALF, bronchoalveolar lavage fluid.