Figure 3:

Effect of polyphosphates on factor H proteolysis by FXIa. (A) Complement factor H (400 nM) was incubated with FXIa (10 nM) for selected times (0-2 hours) at 37°C in the presence or absence of 10 μM or 50 μM short or long polyP. (B) CFH cleavage in the absence or presence of short or long polyP (50 μM) was quantified by densitometry.

* indicates between-groups differences with P < 0.01. Two-way ANOVA was used for statistical comparisons. Data are mean ± SD (n = 3).