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. 2017 Oct 25;19(12):1348–1356. doi: 10.1111/jch.13108

Table 1.

Summary of the studies included in the network meta‐analysis

Trials/author Year Duration, y Blinding Treatment 1 Treatment 2
Drugs Size Age BP, mm Hg NOD Drugs Size Age BP, mm Hg NOD
Park et al 2015 3.0 – ACEI 409 60 – 7 Placebo 409 61 – 49
ADaPT 2012 4.0 Nonblind ACEI 896 69 147/87 151 Diuretic 423 69 144/87 76
EMPHASIS‐HF 2012 1.8 – ARB 894 69 – 33 Placebo 952 69 – 36
COPE <60‐1 2012 3.0 Nonblind ARB 612 55 153/92 14 BB 555 54 153/92 19
COPE <60‐2 2012 3.0 Nonblind ARB 612 55 153/92 14 Diuretics 593 55 153/92 17
COPE <60‐3 2012 3.0 Nonblind BB 555 54 153/92 19 Diuretics 593 55 153/92 17
COPE >60‐1 2012 3.0 Nonblind ARB 498 73 155/85 7 BB 534 72 155/85 18
COPE >60‐2 2012 3.0 Nonblind ARB 498 73 155/85 7 Diuretics 501 73 155/85 15
COPE > 60‐3 2012 3.0 Nonblind BB 534 72 155/85 18 Diuretics 501 73 155/85 15
SPARCL 2011 1.0 ‐ ACEI 1905 61 136/80 166 Placebo 1898 61 136/80 115
NAVIGAROR 2010 6.0 Double‐blind ARB 4631 64 139.4/82.5 1532 Placebo 4675 64 139.9/82.6 1722
HIJ‐CREATE 2009 4.2 – ARB 645 65 135.5/75.8 7 Placebo 624 65 135/75.6 18
Kyoto Heart 2009 3.3 – ARB 1126 66 157/88 58 Placebo 1108 66 157/88 86
CASE‐J 2008 3.2 – ARB 1343 64 162.5/91.6 38 CCB 1342 64 163.2/91.8 59
IMAGINE 2008 3.0 Double‐blind ACEI 1159 61 122/70 28 Placebo 1141 61 121/70 35
PRoFESS 2008 2.5 – ARB 7306 66 144.1/83.8 125 Placebo 7283 66 144.2/83.8 151
TRANSCEND 2008 4.7 Double‐blind ARB 1895 67 140.7/81.8 209 Placebo 1913 67 141.3/82 245
AASK‐1 2006 3.8 Double‐blind ACEI 410 54 150/96 45 BB 405 54 150/96 70
AASK‐2 2006 3.8 Double‐blind ACEI 410 54 150/96 45 CCB 202 54 150/96 32
AASK‐3 2006 3.8 Double‐blind BB 405 54 150/96 70 CCB 202 54 150/96 32
DREAM 2006 3.0 Double‐blind ACEI 2623 55 136.1/83.4 449 Placebo 2646 55 136/83.4 489
ASCOT 2005 5.5 – BB 7071 63 163.0/94.5 799 CCB 7087 63 164.1/94.8 567
CHARM 2005 3.1 Single‐blind ARB 2715 66 130/‐ 163 Placebo 2721 66 131/‐ 202
FEVER 2005 3.3 Double‐blind CCB 4841 62 159/92 177 Placebo 4870 62 159/93 154
PEACE 2004 4.8 Double‐blind ACEI 3432 64 134/78 335 Placebo 3472 64 133/78 399
VALUE 2004 4.2 Double‐blind ARB 5032 67 154.5/87.4 580 CCB 4963 67 154.8/87.6 718
ALPINE 2003 1.0 Double‐blind ARB 196 55 – 1 Diuretic 196 55 – 8
ANBP2 2003 4.1 – ACEI 2800 72 167/91 138 Diuretic 2826 72 168/91 200
CHARM 2003 3.1 Double‐blind ARB 1630 66 130.6/76.6 163 Placebo 1646 66 131.1/76.7 202
EUROPA 2003 4.3 Double‐blind ACEI 5389 60 137/82 389 Placebo 5327 60 137/82 397
INVEST 2003 2.7 – CCB 8098 66 149.5/86.3 665 Placebo 8078 66 149.5/86.3 569
SCOPE 2003 3.7 Double‐blind ARB 2168 76 166/90.3 93 Placebo 2175 76 166.5/90.4 115
SOLVD 2003 2.9 Double‐blind ACEI 153 56 127.4/77.8 9 Placebo 138 57 128.2/79.7 31
ALLHAT‐1 2002 4.0 Double‐blind ACEI 4096 67 146/84 119 CCB 3954 67 146/84 154
ALLHAT‐2 2002 4.0 Double‐blind CCB 3954 67 146/84 154 Diuretic 6766 67 146/84 302
ALLHAT‐3 2002 4.0 Double‐blind ACEI 4096 67 146/84 119 Diuretic 6766 67 146/84 302
LIFE 2002 4.8 Double‐blind ARB 4019 67 174.3/97.9 241 BB 3979 67 174.5/97.7 319
HOPE 2001 4.5 Double‐blind ACEI 2837 66 136.4/78.2 102 Placebo 2883 66 136.7/78.7 155
INSIGHT 2000 3.0 Double‐blind CCB 2508 60‐70 – 96 Diuretic 2511 60‐70 – 137
NOEDIL 2000 4.5 – BB+diuretic 5122 60 173.4/105.7 251 CCB 5023 61 173.5/105.8 216
CAPPP 1999 6.1 – ACEI 5183 52 161.8/99.8 337 BB+diuretic 5230 53 159.6/98.1 380
STOP‐1 1999 4.0 Double‐blind ACEI 1970 76 187/101 93 BB 1960 76 187/101 97
STOP‐2 1999 4.0 Double‐blind ACEI 1970 76 187/101 93 CCB 1965 76 187/101 95
STOP‐3 1999 4.0 Double‐blind BB 1960 76 187/101 97 CCB 1965 76 187/101 95
SHEP 1998 3.0 Double‐blind Diuretic 1631 >60 190/90 140 Placebo 1578 >60 190/90 118
MRC‐E‐1 1992 5.8 Single‐blind BB 1102 70 183/91 37 Diuretic 1081 70 183/91 43
MRC‐E‐2 1992 5.8 Single‐blind BB 1102 70 183/91 37 Placebo 2213 70 183/91 34
MRC‐E‐3 1992 5.8 Single‐blind Diuretic 1081 70 183/91 43 Placebo 2213 70 183/91 34
EWPHE 1991 4.7 – Diuretic 416 >60 – 29 Placebo 424 >60 – 20
HAPPHY 1987 3.8 – BB 3297 52 166/107 86 Diuretic 3272 52 166/107 75
MRC 1985 4.9 Single‐blind BB 4300 51 158/98 43 Diuretic 4240 51 158/98 106

Abbreviations: ACEI, angiotensin‐converting enzyme inhibitor; ARB, angiotensin II receptor blocker; BB, β‐blocker; BP, blood pressure; CCB, calcium channel blocker; NOD, new‐onset diabetes mellitus.