Table 2.

Main actions of peptide hormones catabolized by neprilysin

Name	Action
Adrenomedullin	Circulatory peptide hormone causing systemic vasodilation and new angiogenesis
Angiotensin II	Circulatory peptide hormone causing systemic vasoconstriction and cardiovascular remodeling
Bradykinin	Circulatory peptide hormone causing systemic vasodilation and cough stimulation
Endothelin‐1	Circulatory peptide hormone causing systemic vasoconstriction
Glucagon	Peptide hormone released from the α‐cells of the pancreas catalyzing glycogen and increasing blood glucose levels
Natriuretic peptides	Circulatory peptide hormones causing systemic vasodilation and increasing diuresis and natriuresis
Neurotensin	Circulatory neuropeptide hormone regulating the release of luteinizing and prolactin hormone release and causing systemic vasodilation through its interaction with the dopaminergic system
Oxytocin	Circulatory peptide hormone released from the paraventricular nucleus of the brain and facilitating child birth
Substance P	Circulatory neuropeptide hormone acting as a neurotransmitter and neuromodulator and stimulating cough production
Amyloid β	Increased brain deposition of amyloid β has been implicated as a cause of Alzheimer disease