Table 3.

Demographic and clinical characteristics, and allergometric tests outcomes of patients with suspect hypersensitivity reaction after the administration of the first dose of vaccine.

ID	Sex	Age (ys)	Hypersensitivity symptoms after the first vaccine dose	Time of onset of symptoms	Allergometric tests results for PEG and PS80	Hypersensitivity symptoms after the second vaccine dose with desensitization protocol
1	Male	27	Unilateral left eyelid angioedema, spontaneously regressed within 24 h.	20 h	Negative	None
2	Female	31	Urticaria (wheals localized mainly at lower limbs and face) spontaneously regressed within 48 h.	11 h	Negative	None
3	Female	24	Bilateral eyelid angioedema and pruritus localized at neck and face; regressed within 48 h by taking Cetirizine 10 mg and Prednisone 25 mg.	22 h	Negative	None
4	Female	46	Urticaria (wheals localized mainly upper limbs and face) spontaneously regressed within 72 h.	8.5 h	Negative	None
5	Female	38	Hypotension (90/50 mmHg) not associated with skin rashes or other systemic symptoms. Treated with intravenous Metilprednisolone 40 mg, with regression of symptoms within 30 min.	20 min	Positive to PEG 1:10 intradermal and PS 80 1:10 intradermal	Second dose not administered
6	Female	54	Unilateral right eyelid and labial angioedema, spontaneously regressed within 24 h.	24 h	Negative	None
7	Female	49	Widespread itching with no evidence of skin rash, resolved within approximately 10 days with hydroxyzine 25 mg daily.	20 h	Negative	None

PEG: Polyethylen glycol; PS80: Polysorbate 80