Table 2.
Adjusted relationships of gender‐specific quartiles of thyroid hormones concentrations to elevated BP (n = 12 487)
| Gender‐specific quartiles of FT3/FT4 (pmol/L, range) or TSH (mIU/L, range) | P for trenda | ||||
|---|---|---|---|---|---|
| Level 1 | Level 2 | Level 3 | Level 4 | ||
| FT3 concentration (pmol/L, range, males) | 3.50‐5.17 | 5.18‐5.46 | 5.47‐5.77 | 5.78‐6.50 | ‐ |
| FT3 concentration (pmol/L, range, females) | 3.50‐4.66 | 4.67‐4.94 | 4.95‐5.23 | 5.24‐6.50 | ‐ |
| No. of subjects | 3211 | 3072 | 3041 | 3163 | ‐ |
| No. of elevated BPb | 1551 | 1529 | 1591 | 1661 | ‐ |
| Crude | Reference | 1.06 (0.96, 1.17)c | 1.17 (1.06, 1.30) | 1.18 (1.07, 1.31) | <0.001 |
| Age‐ and BMI‐adjusted | Reference | 1.10 (0.99, 1.22) | 1.25 (1.12, 1.39) | 1.32 (1.18, 1.47) | <0.0001 |
| Multiple adjustedd | Reference | 1.08 (0.97, 1.21) | 1.24 (1.12, 1.39) | 1.32 (1.18, 1.47) | <0.0001 |
| FT4 concentration (pmol/L, range, males) | 11.50‐15.31 | 15.32‐16.60 | 16.61‐18.02 | 18.03‐22.69 | ‐ |
| FT4 concentration (pmol/L, range, females) | 11.50‐14.27 | 14.28‐15.46 | 15.47‐16.74 | 16.75‐22.57 | ‐ |
| No. of subjects | 3135 | 3130 | 3082 | 3140 | ‐ |
| No. of elevated BPb | 1556 | 1614 | 1554 | 1608 | ‐ |
| Crude | Reference | 1.08 (0.98, 1.19) | 1.03 (0.93, 1.14) | 1.07 (0.97, 1.18) | 0.37 |
| Age‐ and BMI‐adjusted | Reference | 1.19 (1.07, 1.33) | 1.18 (1.06, 1.31) | 1.27 (1.14, 1.41) | <0.0001 |
| Multiple adjustedd | Reference | 1.18 (1.06, 1.32) | 1.18 (1.06, 1.31) | 1.24 (1.11, 1.38) | <0.001 |
| TSH concentration (mIU/L, range, males) | 0.55‐1.29 | 1.30‐1.74 | 1.75‐2.35 | 2.36‐4.77 | ‐ |
| TSH concentration (mIU/L, range, females) | 0.55‐1.51 | 1.52‐2.10 | 2.11‐2.86 | 2.87‐4.78 | ‐ |
| No. of subjects | 3129 | 3117 | 3114 | 3127 | ‐ |
| No. of elevated BPb | 1530 | 1579 | 1607 | 1616 | ‐ |
| Crude | Reference | 1.07 (0.97, 1.19) | 1.11 (1.01, 1.23) | 1.12 (1.01, 1.23) | 0.02 |
| Age‐ and BMI‐adjusted | Reference | 1.07 (0.96, 1.19) | 1.08 (0.97, 1.20) | 1.07 (0.96, 1.19) | 0.25 |
| Multiple adjustedd | Reference | 1.06 (0.96, 1.19) | 1.06 (0.95, 1.18) | 1.03 (0.93, 1.15) | 0.58 |
BMI, body mass index; BP, blood pressure; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyroid‐stimulating hormone.
a
Multiple logistic regression analysis.
b
Elevated BP is defined as SBP ranging from 120 to 139 mmHg and/or DBP ranging from 80 to 89 mmHg, according to the JNC 8 criteria.
c
Adjusted odds ratios (95% confidence interval; all such values).
d
Adjusted for age, body mass index, waist, smoking status, alcohol‐consumption status, diabetes, hyperlipidaemia and family history of cardiovascular disease, hypertension, hyperlipidemia, and diabetes.