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. 2018 Oct 30;20(12):1731–1738. doi: 10.1111/jch.13413

Table 1.

Baseline characteristics

Before matching After matching
Fixed‐dose combination Free combination P‐value Fixed‐dose combination Free combination P‐value
(n = 18 227) (n = 4876) (n = 13 176) (n = 4392)
Demographics
Male, n (%) 9785 (53.7) 2633 (54.0) 0.707 6968 (52.9) 2352 (53.6) 0.453
Age, mean (SD) 58.72 (13.42) 60.01 (14.20) <0.001 58.79 (13.48) 58.98 (13.80) 0.420
Age, n (%)
18‐29 179 (1.0) 47 (1.0) <0.001 124 (0.9) 46 (1.0) 0.981
30‐39 1057 (5.8) 269 (5.5) 741 (5.6) 251 (5.7)
40‐49 3446 (18.9) 897 (18.4) 2621 (19.9) 859 (19.6)
50‐59 5397 (29.6) 1287 (26.4) 3727 (28.3) 1235 (28.1)
60‐69 3939 (21.6) 1028 (21.1) 2798 (21.2) 935 (21.3)
>69 4209 (23.1) 1348 (27.6) 3165 (24.0) 1066 (24.3)
Comorbidities, n (%)
Diabetes mellitus 4293 (23.6) 1166 (23.9) 0.612 3040 (23.1) 1021 (23.2) 0.828
Dyslipidemia 3512 (19.3) 984 (20.2) 0.159 2534 (19.2) 876 (19.9) 0.311
Chronic kidney disease 919 (5.0) 319 (6.5) <0.001 585 (4.4) 213 (4.8) 0.277
Coronary artery disease 1599 (8.8) 533 (10.9) <0.001 1056 (8.0) 383 (8.7) 0.148
Peripheral artery disease 244 (1.3) 78 (1.6) 0.189 185 (1.4) 64 (1.5) 0.854
Congestive heart failure 570 (3.1) 299 (6.1) <0.001 73 (0.6) 32 (0.7) 0.235
Charlson score, mean (SD) 1.16 (1.56) 1.28 (1.62) <0.001 1.10 (1.51) 1.14 (1.53) 0.201
Charlson score, n (%)
0 9481 (52.0) 2354 (48.3) <0.001 7042 (53.4) 2305 (52.5) 0.563
1 2508 (13.8) 710 (14.6) 1752 (13.3) 590 (13.4)
2 3087 (16.9) 838 (17.2) 2243 (17.0) 747 (17.0)
3+ 3151 (17.3) 974 (20.0) 2139 (16.2) 750 (17.1)
Baseline medications, n (%)
Antiplatelet agents 5350 (29.4) 1586 (32.5) <0.001 3754 (28.5) 1308 (29.8) 0.106
Calcium channel blocker 10 728 (58.9) 3072 (63.0) <0.001 8267 (62.7) 2758 (62.8) 0.964
Beta‐blocker 6954 (38.2) 2065 (42.4) <0.001 5217 (39.6) 1731 (39.4) 0.845
Other antihypertensive drugs 887 (4.9) 351 (7.2) <0.001 373 (2.8) 114 (2.6) 0.442
Statins 3778 (20.7) 1057 (21.7) 0.153 2671 (20.3) 922 (21.0) 0.315
Oral antidiabetic agents 4827 (26.5) 1243 (25.5) 0.168 3439 (26.1) 1100 (25.0) 0.173