Table 2.
Use of antihypertensive comedications in patients on fixed‐dose vs free‐dose combinations
| Ramipril/amlodipine combination | Candesartan/amlodipine combination | |||||||
|---|---|---|---|---|---|---|---|---|
| Fixed‐dose N = 10 938 | Free‐dose N = 60 525 | Adj. OR (95% CI)a | P value | Fixed‐dose N = 1413 | Free‐dose N = 9082 | Adj. OR (95% CI)a | P value | |
| Any | 53.1 | 69.5 | 0.78 (0.72‐0.84) | < .001 | 44.9 | 64.8 | 0.55 (0.48‐0.61) | < .001 |
| Diuretic | 21.0 | 36.2 | 0.58 (0.56‐0.60) | < .001 | 18.7 | 35.3 | 0.54 (0.46‐0.62) | < .001 |
| β‐blocker | 36.9 | 48.1 | 0.73 (0.70‐0.76) | < .001 | 31.1 | 44.4 | 0.67 (0.59‐0.76) | < .001 |
| CA | 3.2 | 4.0 | 0.88 (0.78‐0.98) | .025 | 3.6 | 5.3 | 0.76 (0.56‐1.03) | .072 |
| ACE‐i | 6.2 | 13.3 | 0.42 (0.39‐0.46) | < .001 | 3.3 | 4.1 | 0.89 (0.64‐1.22) | .456 |
| ARB | 7.2 | 7.0 | 0.99 (0.91‐1.07) | .786 | 6.7 | 10.3 | 0.62 (0.50‐0.78) | < .001 |
ACE‐i, angiotensin‐converting enzyme inhibitor; Adj., adjusted; ARB, angiotensin receptor blocker; CA, calcium antagonist.
a
Adjusted for age, sex, region, and comorbidity.