Table 3.
Multivariate analysis of the study
| Parameters | In/Out | R 2 increment% | Beta coeff. | Lower CI | Upper CI | P value |
|---|---|---|---|---|---|---|
| Dependent variable MMSE | ||||||
| Age | In | 9.7 | −0.102 | −0.142 | −0.062 | <0.001 |
| Education | In | 58.1 | 7.159 | 6.137 | 8.354 | <0.001 |
| cf‐PWV | In | 1.0 | −0.209 | −0.409 | −0.010 | 0.040 |
| Ηt | In | 1.2 | 0.139 | 0.022 | 0.257 | 0.020 |
| GFR‐MDRD | Out | ‐ | ‐ | ‐ | ‐ | |
| R 2 = 0.700 | ||||||
| (a) Dependent variable MMSE without age and aPP | ||||||
| Education | In | 57.9 | 8.031 | 6.891 | 9.171 | <0.001 |
| Ht | In | 4.5 | 0.174 | 0.037 | 0.311 | 0.014 |
| cf‐PWV | In | 1.5 | −0.233 | −0.446 | −0.019 | 0.029 |
| GFR‐MDRD | In | 1.1 | 0.020 | 0.001 | 0.039 | 0.032 |
| R 2 = 0.650 | ||||||
| (b) Dependent variable MMSE without age and cf‐PWV | ||||||
| Education | In | 58 | 7.949 | 6.776 | 9.123 | <0.001 |
| aPP | In | 1.1 | −0.043 | −0.081 | −0.005 | 0.026 |
| LDL | In | 1.3 | 0.012 | 0.001 | 0.023 | 0.035 |
| Statin | In | 1.5 | −1.375 | −2.622 | −0.129 | 0.031 |
| GFR‐MDRD | In | 4.3 | 0.018 | 0.001 | 0.037 | 0.050 |
| R 2 = 0.663 | ||||||
| Dependent variable Clock‐test | ||||||
| Education | In | 15.4 | 1.058 | 0.663 | 1.454 | <0.001 |
| aPP | In | 2.2 | −0.012 | −0.023 | 0.001 | 0.035 |
| GFR‐MDRD | In | 24.2 | 0.019 | 0.014 | 0.025 | <0.001 |
| Age | Out | ‐ | ‐ | ‐ | ‐ | |
| R 2 = 0.419 | ||||||
| Dependent variable IADL | ||||||
| Age | In | 32.5 | 0.327 | 0.039 | 0.138 | 0.001 |
| Education | In | 6.3 | −0.493 | −3.755 | −1.155 | <0.001 |
| bPP | In | 1.1 | 0.541 | 0.003 | 0.069 | 0.032 |
| GFR‐MDRD | In | 7.1 | −0.525 | −0.056 | −0.015 | <0.001 |
| R 2 = 0.678 | ||||||
aPP, aortic pulse pressure; bPP, brachial pulse pressure; cf‐PWV, carotid femoral pulse wave velocity; CI, confidence interval; GFR‐MDRD, Glomerular Filtration Rate‐Modification of Diet in Renal Disease; Ht, hematocrit; LDL, low‐density lipoprotein.