Table 3.
Baseline laboratory data
| Eplerenone (n=98) | Thiazide (n=97) | P value | |
|---|---|---|---|
| Serum creatinine, mg/dL | 0.82±0.24 | 0.76±0.21 | .044 |
| eGFR, mL/min per 1.73 m2 | 67.0±18.2 | 76.2±47.8 | .078 |
| Uric acid, mg/dL | 5.7±1.6 | 5.4±1.4 | .205 |
| Serum potassium, mEq/L | 4.10±0.42 | 4.17±0.45 | .268 |
| Total cholesterol, mg/dL | 182±28 | 183±30 | .837 |
| Triglycerides, mg/dL | 117±62 | 128±120 | .432 |
| HDL cholesterol, mg/dL | 57±17 | 60±16 | .295 |
| Blood glucose, mg/dL | 105±21 | 107±33 | .580 |
| Glycated hemoglobin, % | 5.8±0.5 | 5.9±0.5 | .250 |
| Plasma renin activity, ng/mL per h | 3.2±4.5 | 2.5±3.7 | .251 |
| Plasma aldosterone, pg/mL | 76.5±48.3 | 68.4±32.1 | .177 |
| BNP, pg/mL | 45.9±60.9 | 44.0±53.8 | .839 |
| UACR, mg/gCr | 90.9±120.8 | 179.5±584.2 | .146 |
| (mg/mmolCr) | 9.09±12.1 | 18.0±58.4 | |
| Urine protein, g/gCr | 0.19±0.21 | 0.27±0.48 | .252 |
| baPWV, cm/s | 1896±502 | 1892±432 | .966 |
Data are mean±SD. Abbreviations: baPWV, brachial‐ankle pulse wave velocity; BNP, brain natriuretic peptide; eGFR, estimated glomerular filtration rate; HDL, high‐density lipoprotein; UACR, urinary albumin/creatinine ratio.