Table 4.

Multivariable‐adjusted cox regression analyses of all‐cause mortality, cardiovascular mortality, and renal and cardiovascular events in CKD patients with different levels of nighttime BP load

	All‐cause mortality	Cardiovascular mortality	Renal events	Cardiovascular events
Nighttime SBP load
Tertile 1	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]
Tertile 2	0.88 (0.20–3.85), P=.86	2.94 (0.33–25.95), P=.33	1.11 (0.54–2.30), P=.77	2.98 (0.83–10.62), P=.09
Tertile 3	2.58 (0.69–9.64), P=.16	6.81 (0.85–54.67), P=.07	2.21 (1.12–4.38), P=.02	5.34 (1.58–18.04), P=.007
Nighttime DBP load
Tertile 1	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]
Tertile 2	3.16 (0.82–12.14), P=.09	4.44 (0.91–21.64), P=.06	1.30 (0.63–2.70), P=.47	3.59 (1.22–10.58), P=.02
Tertile 3	6.73 (1.79–25.20), P=.005	7.18 (1.47–35.03), P=.01	2.40 (1.17–4.92), P=.02	5.87 (1.97–17.52), P=.002

Data are expressed as hazard ratios (95% confidence intervals), followed by P value.

Hazard ratios were adjusted for age, sex (female=0, male=1), diabetes mellitus (no=0, yes=1), smoking and drinking (no=0, yes=1), body mass index, history of cardiovascular disease (no=0, yes=1), estimated glomerular filtration rate, hemoglobin, phosphate, cholesterol, proteinuria, and renin‐angiotensin system blockade (no=0, yes=1). BP indicates blood pressure; CKD, chronic kidney disease; DBP, diastolic blood pressure; SBP, systolic blood pressure.