Figure 2.

Principal component analysis (PCA) on the WPD-loops of the crystal structures of PTP1B and YopH. (A) Relative mobility of each residue in the projection of PC1, with residue numbers and names provided above and below, respectively, for both PTPs. (B and C) Projection of PC1 onto representative structures of (B) PTP1B and (C) YopH. The color gradient on the WPD-loop indicates the transition from an open (red) to a closed (blue) WPD-loop conformation along PC1 (see Figure S7 for projections onto each structure). The other key catalytic loops are labeled as in Figure 1.