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. 2021 Apr 8;16(4):e0249485. doi: 10.1371/journal.pone.0249485

Table 1. Mole fraction solubility (xe) values of simvastatin (SIM) in water (H2O) and various micellar solutions of different non-ionic surfactants at T = 300.2 K to 320.2 K and p = 0.1 MPaa.

Samples xe
T = 300.2 K T = 310.2 K T = 320.2 K
H2O 7.57 x 10−7 1.29 x 10−6 1.94 x 10−6
1 mM T80 9.37 x 10−5 1.29 x 10−4 1.77 x 10−4
5 mM T80 5.00 x 10−4 6.36 x 10−4 8.27 x 10−4
10 mM T80 7.34 x 10−4 9.32 x 10−4 1.18 x 10−3
20 mM T80 1.08 x 10−3 1.35 x 10−3 1.68 x 10−3
1 mM T20 4.69 x 10−5 6.42 x 10−5 8.80 x 10−5
5 mM T20 1.94 x 10−4 2.52 x 10−4 3.31 x 10−4
10 mM T20 4.84 x 10−4 6.45 x 10−4 8.06 x 10−4
20 mM T20 7.18 x 10−4 9.13 x 10−4 1.16 x 10−3
1 mM M52 2.75 x 10−4 3.72 x 10−4 4.78 x 10−4
5 mM M52 1.54 x 10−3 1.90 x 10−3 2.33 x 10−3
10 mM M52 3.60 x 10−3 4.29 x 10−3 5.20 x 10−3
20 mM M52 4.67 x 10−3 5.62 x 10−3 6.56 x 10−3
1 mM M59 4.92 x 10−4 6.61 x 10−4 9.17 x 10−4
5 mM M59 2.28 x 10−3 2.84 x 10−3 3.54 x 10−3
10 mM M59 6.01 x 10−3 7.03 x 10−3 8.44 x 10−3
20 mM M59 1.15 x 10−2 1.33 x 10−2 1.54 x 10−2
1 mM B35 1.35 x 10−4 1.87 x 10−4 2.53 x 10−4
5 mM B35 3.43 x 10−4 5.48 x 10−4 8.15 x 10−4
10 mM B35 1.13 x 10−3 1.39 x 10−3 1.76 x 10−3
20 mM B35 2.71 x 10−3 3.25 x 10−3 3.97 x 10−3
1 mM B58 9.11 x 10−5 1.37 x 10−4 1.94 x 10−4
5 mM B58 2.55 x 10−4 3.36 x 10−4 4.55 x 10−4
10 mM B58 4.34 x 10−4 5.57 x 10−4 7.55 x 10−4
20 mM B58 3.74 x 10−3 4.47 x 10−3 5.52 x 10−3
xidl 7.16 x 10−2 9.39 x 10−2 1.22 x 10−1

aThe relative uncertainties ur are ur(T) = 0.016, ur(p) = 0.003 and ur(xe) = 0.014.