Table 1. Mole fraction solubility (xe) values of simvastatin (SIM) in water (H2O) and various micellar solutions of different non-ionic surfactants at T = 300.2 K to 320.2 K and p = 0.1 MPaa.
Samples | xe | ||
---|---|---|---|
T = 300.2 K | T = 310.2 K | T = 320.2 K | |
H2O | 7.57 x 10−7 | 1.29 x 10−6 | 1.94 x 10−6 |
1 mM T80 | 9.37 x 10−5 | 1.29 x 10−4 | 1.77 x 10−4 |
5 mM T80 | 5.00 x 10−4 | 6.36 x 10−4 | 8.27 x 10−4 |
10 mM T80 | 7.34 x 10−4 | 9.32 x 10−4 | 1.18 x 10−3 |
20 mM T80 | 1.08 x 10−3 | 1.35 x 10−3 | 1.68 x 10−3 |
1 mM T20 | 4.69 x 10−5 | 6.42 x 10−5 | 8.80 x 10−5 |
5 mM T20 | 1.94 x 10−4 | 2.52 x 10−4 | 3.31 x 10−4 |
10 mM T20 | 4.84 x 10−4 | 6.45 x 10−4 | 8.06 x 10−4 |
20 mM T20 | 7.18 x 10−4 | 9.13 x 10−4 | 1.16 x 10−3 |
1 mM M52 | 2.75 x 10−4 | 3.72 x 10−4 | 4.78 x 10−4 |
5 mM M52 | 1.54 x 10−3 | 1.90 x 10−3 | 2.33 x 10−3 |
10 mM M52 | 3.60 x 10−3 | 4.29 x 10−3 | 5.20 x 10−3 |
20 mM M52 | 4.67 x 10−3 | 5.62 x 10−3 | 6.56 x 10−3 |
1 mM M59 | 4.92 x 10−4 | 6.61 x 10−4 | 9.17 x 10−4 |
5 mM M59 | 2.28 x 10−3 | 2.84 x 10−3 | 3.54 x 10−3 |
10 mM M59 | 6.01 x 10−3 | 7.03 x 10−3 | 8.44 x 10−3 |
20 mM M59 | 1.15 x 10−2 | 1.33 x 10−2 | 1.54 x 10−2 |
1 mM B35 | 1.35 x 10−4 | 1.87 x 10−4 | 2.53 x 10−4 |
5 mM B35 | 3.43 x 10−4 | 5.48 x 10−4 | 8.15 x 10−4 |
10 mM B35 | 1.13 x 10−3 | 1.39 x 10−3 | 1.76 x 10−3 |
20 mM B35 | 2.71 x 10−3 | 3.25 x 10−3 | 3.97 x 10−3 |
1 mM B58 | 9.11 x 10−5 | 1.37 x 10−4 | 1.94 x 10−4 |
5 mM B58 | 2.55 x 10−4 | 3.36 x 10−4 | 4.55 x 10−4 |
10 mM B58 | 4.34 x 10−4 | 5.57 x 10−4 | 7.55 x 10−4 |
20 mM B58 | 3.74 x 10−3 | 4.47 x 10−3 | 5.52 x 10−3 |
xidl | 7.16 x 10−2 | 9.39 x 10−2 | 1.22 x 10−1 |
aThe relative uncertainties ur are ur(T) = 0.016, ur(p) = 0.003 and ur(xe) = 0.014.