Figure 2.

Administration of a single dose of the nitric oxide (NO)–donating lozenge significantly reduces both systolic and diastolic blood pressure after 20 and 60 minutes compared with baseline. *Statistical comparison compared with baseline; #statistical comparison between 20 and 60 minutes. Compared with placebo, the NO‐donating lozenge led to a significant reduction in diastolic blood pressure at 20 minutes and a significant reduction in systolic and diastolic blood pressure after 60 minutes. @Statistical comparison to placebo determined by two‐tailed t test. Data are presented as average±standard error of the mean of 30 patients in the Neo40 group and 10 in the crossover placebo group.