Synergistic risk of systemic hemodynamic atherothrombotic syndrome (SHATS) on cardiovascular event and organ damage worsened by a vicious cycle of hemodynamic stress and vascular damage. FMD indicates flow‐mediated dilatation of the brachial artery; PWV, pulse wave velocity; IMT, intima‐media thickness of the carotid artery; HTN, hypertension; BPV, blood pressure variability; AI, augmentation index.