Table 2.
Baseline Characteristics Across Tertiles of Plasma PTH
N=292 | First Tertile | Second Tertile | Third Tertile |
---|---|---|---|
Patients, No. | 96 | 99 | 97 |
PTH, pg/mL (normal range 15–65) | 35 (30–39)a | 49 (46–53)a | 69 (61–82)a |
Age, y | 59±13 | 61±10 | 61±11 |
Women, No. (%) | 49 (51) | 52 (53) | 53 (55) |
Smokers, No. (%) | 18 (19) | 10 (10) | 11 (11) |
Type II diabetes, No. (%) | 25 (26) | 14 (14) | 20 (21) |
Mean SBP, mm Hg | 128±11a | 126±12a | 130±12a |
Mean DBP, mm Hg | 77±8 | 76±8 | 78±9 |
Mean daytime SBP, mm Hg | 131±12 | 130±12 | 133±13 |
Mean daytime DBP, mm Hg | 79±9 | 79±9 | 80±10 |
Mean nocturnal SBP, mm Hg | 114±13a | 113±14a | 119±15a |
Mean nocturnal DBP, mm Hg | 67±8 | 66±9 | 69±9 |
BMI, kg/m2 | 28±4a | 29±5a | 30±5a |
LDL cholesterol, mg/dL | 118±44 | 119±35 | 112±35 |
Glycated hemoglobin, % | 5.7 (5.4–6.3) | 5.7 (5.4–6) | 5.7 (5.5–6.1) |
eGFR, mL/min/m2 | 84±18a | 80±16a | 76±21a |
eGFR <60 mL/min/m2, No. (%) | 10 (10)a | 11 (10)a | 20 (21)a |
25(OH)D, ng/mL | 32 (22–38)a | 28 (24–35)a | 24 (19–32)a |
Calcium, mmol/L | 2.43±0.09a | 2.39±0.08a | 2.37±0.12a |
Phosphate, mmol/L | 1 (0.9–1.1)a | 0.95 (0.86–1.08)a | 0.93 (0.8–1.06)a |
NT‐proBNP, pg/mL | 67 (44–135) | 87 (47–165) | 98 (46–226) |
Aldosterone, ng/dL | 15 (11–20) | 15 (10–21) | 16 (12–22) |
Primary hyperparathyroidism, No. (%) | 0a | 2 (2)a | 5 (5)a |
Regular medication use, No. (%) | |||
β‐Blocker | 48 (50) | 56 (57) | 52 (54) |
ACE inhibitor | 39 (41) | 41 (41) | 31 (32) |
ARB | 24 (25) | 24 (24) | 33 (34) |
Calcium antagonist | 24 (25) | 23 (23) | 28 (29) |
MR blocker | 0a | 4 (4)a | 6 (6)a |
Loop diuretic | 1 (1)a | 2 (2)a | 8 (8)a |
Thiazide diuretic | 37 (38) | 39 (39) | 44 (45) |
Abbreviations: ACE, angiotensin‐converting enzyme; ARB angiotensin II receptor blocker; BMI, body mass index; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate, calculated according to the Chronic Kidney Disease Epidemiology Collaboration formula; LDL, low‐density lipoprotein; MR, mineralocorticoid receptor; NT‐proBNP, N‐terminal pro‐brain natriuretic peptide; PTH, parathyroid hormone; SBP, systolic blood pressure; 25(OH)D, 25‐hydroxy vitamin D3. Continuous variables are expressed as median (interquartile range) and categorical variables as number (percentage). a P<.05; P for trend using Kruskal‐Wallis test or analysis of variance or chi‐square test as appropriate.