Table 3.
Blood Pressures in mm Hg, Interventions, Median or Mean Years of Follow up, Number of Events, and Hazard Ratios (95% Confidence Intervals)
| Trial | Baseline BP | Target BP | Intervention Arm (Drug Doses are in Milligrams) | Length of Follow up | Difference in Achieved BP | Number of Events | Hazard Ratio(95% Confidence Limits) | ||
|---|---|---|---|---|---|---|---|---|---|
| CAD | Stroke | CAD | Stroke | ||||||
| CONVINCE | 150/87 | <140/90 | Controlled onset verapamil 180 prior to sleepa | 3.0 | 0.1/0.7 | 299 | 251 | 0.82 (0.65–1.03) | 1.15 (0.90–1.48) |
| FACET | 171/95 | <140/90 |
(1) Amlodipine 10 in the eveningb (2) Fosinopril 20 in the am (given in 26% of those in the amlodipine arm) |
2.5–3.5 | 6/0 | 23 | 14 | 1.30 (0.57–2.94) | 2.56 (0.81–8.33) |
| HOPE | 139/79c | Not applicable | Ramipril 10 prior to sleep | 4.0–5.3 | 3.0/1.0 | 1029 | 382 | 0.80 (0.70–0.90) | 0.68 (0.56–0.84) |
| Syst‐China | 170/86 | Decrease in SBP by 20+ to less than 150 |
(1) Nitrendipine 10 at evening, then 20 at evening, then 20 BID (2) Captopril or HCTZ 12.5 in am escalating to 12.5–25 BID |
3.0 | 8.55/3.1 | 16 | 104 | 1.06 (0.39–2.84) | 0.62 (0.42–0.91) |
| Syst‐Eur | 174/86 | Ditto |
(1) Nitrendipine 10 at evening, then 10 BID, then 20 BID (2) Enalapril 5–20 at evening or HCTZ 12.5–25 in am |
2.0 | 10.1/4.5 | 78 | 124 | 0.70 (0.44–1.09) | 0.58 (0.40–0.83) |
Abbreviation: CAD, coronary artery disease.
aThe control arm received either 50 mg of atenolol or 12.5 mg of hydrochlorothiazide in the morning. bThe control arm received fosinopril 20 mg in the morning, and, if BP was not controlled, amlodipine was given at a time not specified; this occurred in 31% in the fosinopril arm. c47% were diagnosed with hypertension.