Table 1.

Agents That Can Interfere With Blood Pressure Control in Older Adults

Medication	Physiologic Effect
Nonsteroidal anti‐inflammatory drugs	Increase sodium and water retention Increase in blood pressure
Glucocorticoids	Dose‐dependent blood pressure elevation
Sex hormones	Minimal blood pressure elevation in postmenopausal women
Acetaminophen	Small increase in blood pressure
Erythropoietin	Blood pressure elevation
Ergotamine	Worsen blood pressure and minimize the effect of antihypertensive agents
Cimetidines	Potentiate the effect of β‐blockers
Grapefruit juice	May cause hypotension when used with calcium channel blockers

Data from Cooney and colleagues16