Table 3.
Investigation of Biomarkers
| Biomarker | Overall (N=72) | Morning Administration (n=36) | Bedtime Administration (n=36) | Comparison Between Groups | |||
|---|---|---|---|---|---|---|---|
| Mean (SD) | P Value | Mean (SD) | P Value | Mean (SD) | P Value | P Value | |
| hsTnT | |||||||
| Change, ng/mL | −0.04 (0.14) | .017 | −0.01 (0.11) | .479 | −0.07 (0.16) | .010 | .067 |
| PAI‐1 | |||||||
| Change, ng/mL | −0.01 (0.24) | .728 | −0.02 (0.24) | .712 | 0.00 (0.23) | .914 | .846 |
| NT‐ProBNP | |||||||
| Change, pg/mL | −0.07 (0.36) | .127 | 0.00 (0.35) | .985 | −0.13 (0.36) | .033 | .116 |
| UACR | |||||||
| Change, mg/g∙Cr | −0.16 (0.36) | .001 | −0.13 (0.41) | .069 | −0.19 (0.31) | .001 | .446 |
Abbreviations: Cr, creatinine; hsTnT, high‐sensitivity troponin T; NT‐ProBNP, N‐terminal pro‐brain natriuretic peptide; PAI‐1, plasminogen activator inhibitor‐1; SD, standard deviation; UACR, urinary albumin/creatinine ratio. Data are shown as logarithmically transformed values.