Table 1. Boolean regulatory functions of each node in the model.

Each function indicates the next state of the node as a function of the current state of its regulators. For simplicity the state of each node is represented with the name of the node. The model is provided in BooleanNet (S1 File) and SBML qual (S2 File) file formats.

Node	Boolean function F	References
pH	pH
Temperature	Temperature
Farnesol	Farnesol
Rim8	pH	[11]
Cyr1	Temperature and not Farnesol	[12–14]
ESCRT	Rim8	[11]
cAMP/PKA	Cyr1
Efg1_active	(ESCRT or cAMP_PKA) and Efg1	[9]
Efg1_T	Brg1 or not Efg1_active	[9,15]
Efg1	Efg1_T	[9]
NRG1_T	not Brg1 and not Ume6 and not (Efg1_active and (ESCRT or cAMP_PKA)) or hyphal_initiation	[10,16]
Nrg1@HAGs	NRG1_T and (not HDACs or HATs)	[10]
Brg1	not Nrg1@HAGs	[16]
Ume6	Brg1 and not Nrg1@HAGs	[17]
HDACs	Brg1	[10]
HATs	Efg1_active and not HDACs	[10,17]
hyphal_initiation	(HATs and Brg1 and not Nrg1@HAGs) or hyphal_initiation	[10]
HAG_transcription	(Brg1 or Ume6) and not Nrg1@HAGs	[18]
hyphal_maintenance	(Ume6 and not Nrg1@HAGs) and hyphal_initiation	[10]