Table 4. Probabilities of completing the YHT in the condition pH = 1 and Farnesol = Temperature = 0, under single-node interventions or WT.
Transition probabilities are estimated from 500 simulated trajectories starting from the yeast attractor corresponding to the given environment (see Fig 2). When a perturbed system’s attractor is different from the WT attractor, it is classified into a phenotype (attractor group) by similar criteria as in Fig 2; see S2 Fig for more details.
| Node | Value | YHT (General) | YHT (Stochastic Propensity) | ||
|---|---|---|---|---|---|
| Complete (Hyphal) | Partial (HL or YL) | Complete (Hyphal) | Partial (HL or YL) | ||
| Brg1 | 0 | 0% | 0% | 0% | 0% |
| Efg1_T, Efg1, Efg1_active | 0 | 0% | 0% | 0% | 0% |
| Efg1 | 1 | 54% | 28% HL, 18% YL | 69% | 14% HL, 17% YL |
| EFG1_T | 1 | 51% | 31% HL, 18% YL | 68% | 13% HL, 19% YL |
| Efg1_active | 1 | 55% | 29% HL, 16% YL | 71% | 10% HL, 19% YL |
| HATs | 0 | 0% | 100% HL | 0% | 100% HL |
| HATs | 1 | 0% | 100% YL | 0% | 100% YL |
| HDACs | 0 | 0% | 100% YL | 0% | 100% YL |
| Nrg1_T, Nrg1@HAGs | 1 | 0% | 0% | 0% | 0% |
| Ume6 | 0 | 0% | 85% HL, 15% YL | 0% | 90% HL, 10% YL |
| Ume6 | 1 | 25% | 66% HL, 9% YL | 36% | 55% HL, 9% YL |
| WT | 37% | 51% HL, 12% YL | 53% | 38% HL, 9% YL | |