Table 1.
Biochemistry and Blood Parameters (A); Blood Pressure, Arterial Stiffness, and Glomerular Filtration Rate (B); Bone Homeostasis and Hormones (C); and Glucose Homeostasis (D)
| Variable | SCD | Controls | P Value |
|---|---|---|---|
| (A) | |||
| Cholesterol total | 146.1±42.6 | 197.5±36.7 | <.001 |
| Triglycerides | 113.6±57.6 | 82.0±38.0 | .006 |
| LDL | 82.8±35.1 | 131.8±32.1 | <.001 |
| HDL | 39.1±10.5 | 50.0±13.4 | <.001 |
| Ferritin | 170.3 (1439.9) | 30.7 (175.8) | <.001 |
| Ferrum | 95.2±36.3 | 94±44.4 | NS |
| Creatinine | 0.60±0.15 | 0.75±0.14 | <.001 |
| Urea | 22±8.2 | 26.6±8.4 | .02 |
| Sodium | 139.5±3.7 | 136.0±1.4 | <.001 |
| Potassium | 4.4±0.4 | 4.1±0.4 | <.001 |
| Hemoglobin, g/dL | 10.8±1.1 | 13.1±1.4 | <.001 |
| Hematocrit, % | 29.7±3.5 | 38.5±3.2 | <.001 |
| MCV, fL | 72.9±6.9 | 85.2±3.5 | <.001 |
| MCHC, g/dL | 36.5±1.2 | 34.4±1.1 | <.001 |
| (B) | |||
| Branchial SBP | 115.1±13.8 | 121.9±11.3 | .02 |
| Branchial DBP | 68.5±8.0 | 80.6±9.1 | <.001 |
| Branchial MAP | 91.8±10.1 | 101.3±9.0 | <.001 |
| Branchial PP | 46.9±10.2 | 41.0±9.9 | .025 |
| Heart rate | 76.4±10.5 | 73.8±10.7 | NS |
| Central SBP | 105.4±17.7 | 108.4±10.0 | NS |
| Central DBP | 70.0±8.3 | 79.8±9.4 | <.001 |
| Central MAP | 87.7±11.5 | 94.1±9.2 | .009 |
| Central PP | 35.4±15.5 | 28.5±6.1 | .01 |
| AIx | 24.9±9.6 | 12.4±10.8 | <.001 |
| PWV, m/s | 7.2±1.4 | 7.1±0.8 | NS |
| MDRD, mL/min/1.73 m2 | 138.0±37.3 | 110.6±20.0 | <.001 |
| (C) | |||
| 25 (OH) D3 | 13.1±8.4 | 32.4±14.2 | <.001 |
| PTH | 32.7±20.4 | 31.0±14.9 | NS |
| Calcium | 9.0±0.6 | 9.0±0.4 | NS |
| Phosphate | 3.5±0.5 | 3.6±0.6 | NS |
| Osteocalcin | 14.1±5.7 | 3.6±0.6 | <.001 |
| TSH | 2.1±1.4 | 1.7±0.7 | NS |
| Cortisol | 316±145.5 | 379.9±244.2 | NS |
| (D) | |||
| Fasting glucose, mg/dL | 81.4±12.5 | 78.9±7.9 | NS |
| Fasting insulin, μU/mL | 5.1±2.7 | 11.3±6.6 | <.001 |
| HOMA‐IR, % | 18.6±10.2 | 41.8±25.7 | <.001 |
| QUICKI | 0.38 (0.5) | 0.35 (0.11) | <.001 |
| HOMA‐β, % | 101.1 (1983.6) | 274.1 (4351.1) | <.001 |
Abbreviations: AIx, augmentation index; DBP, diastolic blood pressure; HDL, high‐density lipoprotein; HOMA‐β, homeostatic model assessment for β‐cell function; HOMA‐IR, homeostatic model assessment for insulin resistance; MAP, mean arterial pressure; LDL, low‐density lipoprotein; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; MDRD, Modification of Diet in Renal Disease; PP, pulse pressure; PTH, parathyroid hormone; PWV, pulse wave velocity; SBP, systolic blood pressure; SCD, TSH, thyroid‐stimulating hormone; QUICKI, All blood pressures are measured in mm Hg.