Table 2.
Parameters of Small Vessel Disease in Groups of Systolic and Diastolic Blood Pressure and Tertiles of Mean Arterial Pressure and Pulse Pressure
| Parameters of Small Vessel Disease | Systolic Blood Pressure, mm Hg | β/OR (95% CI) | P Trend | Diastolic Blood Pressure, mm Hg | β/OR (95% CI) | P Trend | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| <140 (n=88) | 140–159 (n=75) | ≥160 (n=57) | <80 (n=99) | 80–89 (n=78) | ≥90 (n=43) | |||||
| Volume WMH, mL | 34.8 (4.1) | 38.7 (5.1) | 38.1 (37.9) | 0.02 (−0.19, 0.24) | .84 | 33.2 (3.3) | 40.4 (5.1) | 46.2 (7.1) | 0.09 (−0.14, 0.31) | .45 |
| Periventricular WMH, No. (%) | 54 (61.4) | 45 (60.0) | 33 (57.9) | 0.93 (0.65, 1.32) | .68 | 54 (54.5) | 51 (61.4) | 27 (62.8) | 1.34 (0.92, 1.95) | .13 |
| Subcortical WMH, No. (%) | 46 (52.3) | 38 (50.7) | 29 (50.9) | 1.04 (0.73, 1.48) | .83 | 52 (52.2) | 39 (50.0) | 22 (51.2) | 0.98 (0.68, 1.41) | .90 |
| Lacunar infarcts, No. (%) | 21 (24.1) | 21 (28.0) | 17 (29.8) | 1.18 (0.79, 1.76) | .41 | 27 (27.6) | 20 (26.6) | 12 (27.9) | 1.04 (0.69, 1.57) | .86 |
| Microbleeds, No. (%) | 19 (22.1) | 18 (25.0) | 18 (32.1) | 1.38 (0.92, 2.08) | .12 | 20 (20.6) | 24 (32.0) | 11 (26.2) | 1.45 (0.95, 2.21) | .09 |
| Basal, No. (%) | 11 (12.8) | 12 (16.7) | 10 (17.9) | 1.34 (0.82, 2.19) | .25 | 12 (12.4) | 13 (17.3) | 8 (19.0) | 1.61 (0.96, 2.70) | .07 |
| Lobar, No. (%) | 14 (16.3) | 13 (18.1) | 14 (25.0) | 1.33 (0.84, 2.10) | .23 | 15 (15.5) | 18 (24.0) | 8 (19.0) | 1.40 (0.87, 2.27) | .17 |
| Mean Arterial Pressure, mm Hg | β/OR (95% CI) | P Trend | Pulse Pressure, mm Hg | β/OR (95% CI) | P Trend | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| <97 (n=73) | 97–107 (n=73) | >107 (n=74) | <58 (n=74) | 58–69 (n=72) | >69 (n=74) | |||||
| Volume WMH, mL | 32.8 (3.8) | 41.0 (5.1) | 38.1 (5.1) | 0.02 (−0.19, 0.23) | .85 | 33.5 (4.4) | 37.1 (4.9) | 40.3 (4.9) | 0.06 (−0.15, 0.26) | .59 |
| Periventricular WMH, No. (%) | 43 (58.9) | 47 (64.4) | 42 (56.8) | 0.95 (0.46, 1.43) | .78 | 46 (62.2) | 46 (63.9) | 40 (54.1) | 0.81 (0.58, 1.15) | .81 |
| Subcortical WMH, No. (%) | 37 (50.7) | 42 (57.5) | 34 (45.9) | 1.43 (0.67, 1.33) | .74 | 38 (51.4) | 36 (50.0) | 39 (52.3) | 1.11 (0.79, 1.56) | .53 |
| Lacunar infarcts, No. (%) | 18 (25.0) | 22 (30.1) | 19 (25.7) | 1.04 (0.71, 1.52) | .86 | 18 (24.7) | 19 (26.4) | 22 (29.7) | 1.16 (0.79, 1.71) | .46 |
| Microbleeds, No. (%) | 15 (21.1) | 18 (25.7) | 22 (30.1) | 1.40 (0.94, 2.10) | .10 | 17 (23.9) | 19 (27.1) | 19 (26.0) | 1.03 (0.69, 1.53) | .89 |
| Basal, No. (%) | 9 (12.7) | 15 (12.9) | 9 (20.5) | 1.59 (0.97, 2.62) | .07 | 10 (14.1) | 11 (15.7) | 12 (16.4) | 1.06 (0.68, 1.76) | .71 |
| Lobar, No. (%) | 11 (15.5) | 13 (18.6) | 17 (23.3) | 1.39 (0.88, 2.20) | .16 | 12 (16.9) | 14 (20.0) | 15 (20.5) | 1.05 (0.68, 1.63) | .83 |
Abbreviation: WMH, white matter hyperintensity. Missing values: n=3 for volume WMH, n=1 for lacunar infarcts, and n=6 for microbleeds. Data are presented as mean (standard error) or number (percentage), and β or odds ratios (ORs) (per increase in blood pressure group or tertile) (95% confidence interval [CI]), adjusted for age, sex, and duration of antihypertensive treatment.