Table 3.

Logistic Regression Analysis for the Association Between Baseline Levels of Homocysteine and Follow‐Up cf‐PWV and cf‐PWVδ

	Quartile 2 vs Quartile 1 13.7–16.7 vs ≤13.6		Quartile 3 vs Quartile 1 16.8–20.9 vs ≤13.6		Quartile 4 vs Quartile 1 ≥21.0 vs ≤13.6
	OR (95% CI)	P Value	OR (95% CI)	P Value	OR (95% CI)	P Value
cf‐PWV
Unadjusted	2.126 (1.473–3.068)	<.001	3.922 (2.744–5.606)	<.001	4.935 (3.437–7.086)	<.001
Model 1	1.557 (1.046–2.317)	.029	1.769 (1.157–2.705)	.009	2.060 (1.307–3.246)	.002
Model 2	1.481 (0.873–2.511)	.145	1.833 (1.069–3.142)	.028	2.304 (1.261–4.209)	.007
cf‐PWVδ
Unadjusted	1.300 (0.893–1.892)	.172	1.453 (1.050–2.011)	.024	1.588 (1.143–2.205)	.006
Model 1	1.327 (0.906–1.945)	.146	1.700 (1.183–2.442)	.004	1.670 (1.119–2.492)	.012
Model 2	1.656 (1.011–2.711)	.045	1.757 (1.097–2.813)	.019	1.756 (1.058–2.915)	.029

Abbreviations: cf‐PWV, carotid‐femoral pulse wave velocity; cf‐PWVδ, change in carotid‐femoral pulse wave velocity; tHcy, total homocysteine. Levels of tHcy were Ln‐transformed to normalize their distributions. Data are presented as odds ratios (ORs; per standard deviation increase in LntHcy level) and corresponding 95% confidence intervals (CIs). In the logistic regression model, cf‐PWV (PWV ≥12 m/s vs PWV<12 m/s) and PWVδ (PWVδ >0 vs PWVδ ≤0) were treated as the dependent variables. Model 1: adjusted for age, sex; model 2: adjusted for age, sex, hypertension, antihypertensive drugs, diabetes mellitus, current smoking, body mass index, estimated glomerular filtration rate, and levels of serum triglycerides, total cholesterol, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, uric acid, and creatinine.