Table 1.
Genotype and Allele Frequencies of the Pro12Ala and C1431/X PPARγ2 and Trp 64Arg of β‐Adrenergic Receptor Gene Polymorphisms According to Normotensive (RR <140/90 mm Hg) and Hypertensive State (RR ≥140/90 mm Hg)
| Analyzed Genotypes | Hypertensive Women (n=151) | Normotensive Women (n=120) | Whole Group of Postmenopausal Women (N=271) |
|---|---|---|---|
| Genotype | |||
| Pro12Pro | 101 (66.89) | 84 (70.0) | 185 (68.27) |
| Pro12Ala | 44 (29.14) | 32 (26.67) | 76 (28.04) |
| Ala12Ala | 6 (3.97) | 4 (3.33) | 10 (3.69) |
| Chi‐square value (P value) | 0.3149 (.5698) | ||
| Allele frequency | |||
| Pro | 246 (0.815) | 200 (0.833) | 446 (0.823) |
| Ala | 56 (0.185) | 40 (0.167) | 96 (0.177) |
| Chi‐square value (P value) | 0.3230 (.8542) | ||
| OR (95% CI) | 1.1382 (0.7282–1.7790) | ||
| Genotype | |||
| C1431C | 107 (70.86) | 91 (75.83) | 198 (73.07) |
| C1431T | 39 (25.83) | 27 (22.50) | 66 (24.35) |
| T1431T | 5 (3.31) | 2 (1.67) | 7 (2.58) |
| Chi‐square value (P value) | 1.2304 (.5405) | ||
| Allele frequency | |||
| C1431 | 253 (0.838) | 209 (0.871) | 462 (0.852) |
| T1431 | 49 (0.162) | 31 (0.129) | 80 (0.148) |
| Chi‐square value (P value) | 1.1634 (.2808) | ||
| OR (95% CI) | 1.306 (0.8034–2.1222) | ||
| Genotype | |||
| Trp64Trp | 122 (80.79) | 98 (81.67) | 220 (81.18) |
| Trp64Arg | 27 (17.88) | 20 (16.67) | 47 (17.34) |
| Arg64Arg | 2 (1.32) | 2 (1.67) | 4 (1.28) |
| Chi‐square value (P value) | 0.1161 (.9435) | ||
| Allele frequency | |||
| Trp | 271 (0.897) | 216 (0.900) | 487 (0.899) |
| Arg | 31 (0.103) | 24 (0.100) | 55 (0.101) |
| Chi‐square value (P value) | 0.0102 (.9192) | ||
| OR (95% CI) | 0.9713 (0.5536–1.7040) | ||
Abbreviations: CI, confidence interval; OR, odds ratio; PPARγ2, peroxisome proliferator‐activated receptor γ2. Data are expressed as number (percentage) for genotypes and number (frequency) for alleles.