Table 3.
Differences in SBP, DBP, PP, and MAP in Postmenopausal Women According to Genotype Distribution
| Analyzed Group | Analyzed Polymorohism | No. | SBP, Mean±SD | DBP, Mean±SD | PP, Mean±SD | MAP |
|---|---|---|---|---|---|---|
| Whole group | Pro12Pro | 185 | 141.67±22.28 | 88.08±13.54 | 53.59±12.83 | 105.95±15.70 |
| Pro12Ala | 76 | 140.01±22.91 | 86.91±13.73 | 53.11±14.35 | 104.61±15.96 | |
| Ala12Ala | 10 | 142.20±26.93 | 94.50±15.62 | 47.70±11.83 | 110.40±19.32 | |
| All patients | 271 | 141.21±22.57 | 87.99±13.69 | 53.22±13.25 | 105.73±15.89 | |
| Statistical significance | ns | ns | ns | ns | ||
| Whole group | C1431C | 198 | 139.77±21.68 | 87.45±13.04 | 52.32±12.78 | 104.89±15.29 |
| C1431T | 66 | 144.50±23.73 | 88.55±14.31 | 55.95±14.48 | 107.20±16.66 | |
| T1431T | 7 | 151.57±31.26 | 97.43±19.26 | 54.14±16.14 | 115.47±22.70 | |
| All patients | 271 | 141.23±22.52 | 87.98±13.57 | 53.25±13.33 | 105.78±15.89 | |
| Statistical significance | ns | ns | ns | ns | ||
| Whole group | Trp64Trp | 220 | 141.36±22.14 | 88.07±13.64 | 53.29±12.72 | 105.83±15.85 |
| Trp64Arg | 47 | 141.26±23.94 | 87.60±13.51 | 53.66±15.55 | 105.48±16.09 | |
| Arg64Arg | 4 | 133.75±31.69 | 87.25±14.13 | 46.50±20.53 | 102.75±19.34 | |
| All patients | 271 | 141.23±22.52 | 87.98±13.57 | 53.25±13.33 | 105.73±15.89 | |
| Statistical significance | ns | ns | ns | ns | ||
| Hypertension | Pro12Pro | 101 | 158.22±14.97 | 96.75±11.36 | 61.47±10.06 | 122.88±10.27 |
| Pro12Ala | 44 | 155.30±15.62 | 94.75±12.12 | 60.55±12.79 | 120.74±10.99 | |
| Ala12Ala | 6 | 158.67±20.59 | 104.83±9.99 | 53.83±10.65 | 126.00±12.26 | |
| Normal blood pressure | Pro12Pro | 84 | 122.28±10.02 | 77.83±6.94 | 44.45±8.86 | 92.54±6.96 |
| Pro12Ala | 32 | 119.00±12.01 | 76.13±6.70 | 42.88±9.20 | 90.42±7.69 | |
| Ala12Ala | 4 | 117.50±10.66 | 79.00±5.60 | 38.50±6.56 | 91.83±7.02 | |
| All patients | 271 | 141.33±22.45 | 88.01±13.63 | 53.31±13.20 | 105.73±15.89 | |
| Ss | P<.001 | P<.001 | P<.001 (P<.0001a) | P<.001 | ||
| Hypertension | C1431C | 107 | 155.72±14.43 | 95.71±11.35 | 60.01±10.30 | 121.61±9.88 |
| C1431T | 39 | 160.54±15.85 | 96.82±11.81 | 63.72±11.56 | 123.23±11.71 | |
| T1431T | 5 | 165.60±23.84 | 107.00±12.35 | 58.60±16.91 | 131.50±11.79 | |
| Normal blood pressure | C1431C | 91 | 121.02±11.21 | 77.75±6.64 | 43.27±8.91 | 92.17±7.32 |
| C1431T | 27 | 121.33±9.86 | 76.59±7.53 | 44.74±10.41 | 91.51±6.79 | |
| T1431T | 2 | 116.50±12.02 | 73.50±3.54 | 43.00±8.49 | 87.83±6.36 | |
| All patients | 271 | 141.23±22.52 | 87.98±13.57 | 53.25±13.33 | 105.73±15.89 | |
| Ss | P<.001 | P<.001 | P<.001 | P<.001 | ||
| Hypertension | Trp64Trp | 122 | 157.07±15.43 | 96.57±11.50 | 60.50±10.81 | 122.16±10.67 |
| Trp64Arg | 27 | 158.15±15.19 | 95.30±12.51 | 62.85±11.78 | 124.44±10.20 | |
| Arg64Arg | 2 | 159.00±9.90 | 98.50±9.19 | 60.50±0.71 | 118.67±9.43 | |
| Normal blood pressure | Trp64Trp | 98 | 121.80±10.60 | 77.49±7.14 | 44.31±8.51 | 92.26±7.43 |
| Trp64Arg | 20 | 118.45±10.92 | 77.20±5.43 | 41.25±10.64 | 90.95±5.85 | |
| Arg64Arg | 2 | 108.50±19.09 | 76.00±2.83 | 32.50±21.92 | 88.83±4.48 | |
| All patients | 271 | 141.23±22.52 | 87.98±13.57 | 53.25±13.33 | 105.73±15.89 | |
| Ss | P<.001 | P<.001 | P<.001 (P<.0001b) | P<.001 (P<.0001b) | ||
Abbreviations: DBP, diastolic blood pressure; MAP, mean arterial pressure; PP, pulse pressure; SD, standard deviation; SDP, systolic blood pressure; Ss, statistical significance between normotensive and hypertensive patients with the same variant of polymorphism. a P<.0001 between normotensive patients with Ala12Ala and others Pro12Ala polymorphisms of normotensive and hypertensive women. b P<.0001 between normotensive patients with Arg64Arg and others Trp64Arg polymorphisms of normotensive and hypertensive women.