Table 4.
Cluster Analysis of Association between, Genotype Distribution, Selected Metabolic Parameters and the Blood Pressure Value
| Analysed Polymorphisms in Normo‐ and Hypertensive Women | Groupa (Cluster) Number | TC [mg/dL] X±SD | HDL [mg/dL] X±SD | TG [mg/dL] X±SD | LDL [mg/dL] X±SD | UA [mg/dL] X±SD | Lp [g/L] X±SD | PP1,2,3 X±SD | MAP1,2,3 X±SD |
|---|---|---|---|---|---|---|---|---|---|
| Hypertensive women with Pro12Pro polymorphism | 1 (n=96) | 238.00±43.20 | 64.49±15.62 | 123.49±49.59 | 148.76±39.12 | 4.85±1.08 | 0.24±0.34 | 61.32±10.17 | 117.53±11.54 |
| Women with Ala12/X polymorphism | 2 (n=73) | 230.14±39.69 | 64.40±15.38 | 120.53±63.32 | 141.47±4.10 | 4.92±1.13 | 0.24±0.40 | 52.48±14.18 | 104.75±16.25 |
| Normotensive women with Pro12Pro polymorphism | 3 (n=78) | 222.70±40.54 | 62.95±13.09 | 109.38±52.15 | 138.11±37.60 | 4.71±1.10 | 0.18±0.27 | 44.44±9.05 | 92.85±6.89 |
| Unclassified | 4 (n=9) | 223.12±27.63 | 60.86±12.82 | 139.74±44.09 | 134.33±24.77 | 5.20±0.68 | 0.23±0.17 | 47.78±12.55 | 111.59±20.10 |
| Whole group | 230.58±41.25 | 63.87±14.67 | 118.92±54.61 | 142.93±36.98 | 4.84±1.09 | 0.22±0.33 | 53.18±13.21* | 106.16±15.99** | |
| Statistical significance | ns | ns | ns | ns | ns | ns | ** | ** |
Abbreviations: HA, hypertensive patients; HDL, high density lipoproteins; LDL, low density lipoproteins; Lp, lipoprotein; MAP, mean arterial pressure; n, number of analysed subjects; ns, statistically not significant; PP, pulse pressure; SD, standard deviation; TC, total cholesterol; UA, uric acid; X, mean value. **Indicates P value<.0001 (groups with very significant differences are shown in superscript arabic numerals). aGroup 4 does not differ from group 1, 2, 3 because of small number of analysed subjects in this group.