Table 3.
Adjusted Regression Coefficients for Users of TD Monotherapy Compared With Users of Non‐TDs or ACE Inhibitors or ARBs
Outcomes | Drug Groups: TD vs Non‐TD | Drug Groups: TD vs ACE Inhibitors/ARBs | ||||||
---|---|---|---|---|---|---|---|---|
Adjusted Coefficient | SE | P Value | 95% CI | Adjusted Coefficient | SE | P Value | 95% CI | |
Central SBP | 0.445a | 1.047 | .007 | −1.606 to 2.496 | 0.265a | 1.061 | .005 | −1.814 to 2.344 |
Central DBP | −0.954a | 1.161 | <.001 | −3.229 to 1.321 | −1.405b | 1.201 | <.001 | −3.759 to 0.949 |
Central PP | −0.278a | 1.065 | .005 | −1.810 to 2.366 | −0.035b | 1.077 | .003 | −2.077 to 2.146 |
MAP | −0.939a | 1.333 | .002 | −3.552 to 1.674 | −1.519b | 1.370 | .001 | −4.205 to 1.167 |
Central AIx | −0.254b | 0.956 | <.001 | −2.127 to 1.619 | −0.308a | 0.961 | <.001 | −2.191 to 1.575 |
Abbreviations: AIx, augmentation index; DBP, diastolic blood pressure; MAP, mean arterial pressure; PP, pulse pressure; SE, standard error; SBP, systolic blood pressure. Non‐thiazide diuretic Non‐(TD) antihypertensive includes angiotensin‐converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), β‐blockers, calcium channel blockers, and other antihypertensive agents (diuretics [other than thiazide‐type], antiadrenergic agents, and agents acting on the renin‐angiotensin system [excluding ACE inhibitors and ARBs]). In all models, TD was the reference category. aAdjusted for sex, age, quadratic age, body mass index (BMI), quadratic BMI, International Physical Activity Questionnaire, hypercholesterolemia, comorbidities, smoking, alcohol intake, heart rate, and high blood pressure onset date. bAdjusted for all previous variables and height instead of BMI.