Forest plot of mean blood pressure (BP) difference between A+C combination therapy and other combinations. Boxes and solid lines indicate mean difference and 95% confidence interval (CI), respectively, for each study. Diamonds and their width indicate the pooled mean difference and the 95% CI, respectively. A indicates angiotensin‐converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB); A+C, ACE inhibitor/ARB plus CCB; A+D, ACE inhibitor/ARB plus diuretic; BB, β‐blocker; C, calcium channel blocker; CI, confidence interval; D, diuretic. See text for trial expansions.