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Comparison between BRD4-BD1 in complex with 3478 (A) and RVX-208 (B). Polar contacts were found with Pymol. 3478 is hydrogen-bonded with P40–N98 and other 5 water molecules (total 7 hydrogen bonds) while RVX-208 is hydrogen-bonded with N98 and other two water molecules (total 5 hydrogen bonds).
