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. 2021 Mar 23;96(12):e1632–e1645. doi: 10.1212/WNL.0000000000011542

Figure 4. Longitudinal Accumulation of Cerebral Microhemorrhages (CMHs) as a Function of Estimated Years to Symptom Onset.

Figure 4

Plot of CMH count as a function of estimated years from symptom onset (EYO) within mutation noncarriers (blue, n = 127), asymptomatic mutation carriers (green, n = 142), and symptomatic mutation carriers (red, n = 76). Accumulation of CMH is more pronounced (increase to >5 CMHs, above red dashed line) and mostly observed in symptomatic mutation carriers (n = 17, 22.4%) past EYO 0 (black dashed line). Three noncarriers (2.4%) and 6 asymptomatic mutation carriers (4.2%) had new CMHs to a lesser extent (increase to <5 CMHs, under red dashed line).