Table 5.
Topological characteristics of the top 30 nodes in the crosstalk gene-related PPI network, ranked in descending order of degree.
| Node | Label | Degree | Average shortest path length | Betweenness centrality | Closeness centrality | Clustering coefficient | Topological coefficient |
|---|---|---|---|---|---|---|---|
| MYC | DEG_AD_down | 1027 | 2.127525 | 0.466698 | 0.47003 | 5.03E − 04 | 0.001842 |
| HSPB1 | DEG_AD_down | 433 | 2.36959 | 0.184598 | 0.422014 | 0.001636 | 0.003351 |
| VIM | DEG_AD_up | 320 | 2.663301 | 0.116611 | 0.375474 | 0.001763 | 0.005783 |
| KAT5 | DEG_AD_down | 245 | 2.566359 | 0.089476 | 0.389657 | 0.003011 | 0.005621 |
| RPL13 | DEG_AD_down | 234 | 2.589729 | 0.089708 | 0.386141 | 0.001394 | 0.005672 |
| FOS | DEG_AD_up | 226 | 2.883151 | 0.083642 | 0.346843 | 1.97E − 04 | 0.017606 |
| CDH1 | DEG_AD_down | 171 | 2.93191 | 0.058428 | 0.341075 | 0 | 0.025911 |
| TP73 | DEG_AD_down | 137 | 2.61483 | 0.046781 | 0.382434 | 0.006333 | 0.009173 |
| FHL2 | DEG_AD_up | 136 | 2.641085 | 0.057192 | 0.378632 | 0.004031 | 0.00889 |
| CALR | DEG_AD_down | 135 | 2.812464 | 0.046142 | 0.35556 | 0.002764 | 0.010949 |
| GSTK1 | DEG_AD_up | 111 | 2.988459 | 0.035152 | 0.334621 | 0 | 0.026289 |
| MME | DEG_AD_up | 104 | 2.836988 | 0.040386 | 0.352487 | 0.001307 | 0.011694 |
| MED12 | DEG_AD_down | 91 | 2.695615 | 0.030682 | 0.370973 | 0.006105 | 0.012517 |
| CASP7 | DEG_AD_up | 90 | 2.901039 | 0.027131 | 0.344704 | 0.005243 | 0.015603 |
| DNM1 | DEG_AD_down | 84 | 2.960185 | 0.029086 | 0.337817 | 0.001147 | 0.023716 |
| FOXO1 | DEG_AD_up | 67 | 2.977784 | 0.017403 | 0.33582 | 0.004071 | 0.026586 |
| CXCR4 | DEG_AD_up | 65 | 2.998557 | 0.020851 | 0.333494 | 0.003846 | 0.028808 |
| NOS3 | DEG_AD_down | 62 | 2.963647 | 0.018786 | 0.337422 | 0.002644 | 0.027957 |
| NDUFB8 | DEG_AD_up | 56 | 3.042412 | 0.02136 | 0.328687 | 0 | 0.027447 |
| UBC | Other gene | 53 | 2.084824 | 0.149265 | 0.479657 | 0.015965 | 0.027336 |
| NES | DEG_AD_down | 53 | 2.920946 | 0.017012 | 0.342355 | 0.007983 | 0.022954 |
| CDK5R1 | DEG_AD_down | 50 | 3.0176 | 0.0133 | 0.331389 | 0.002449 | 0.037222 |
| NEFL | DEG_AD_down | 49 | 2.913445 | 0.014886 | 0.343236 | 0.008503 | 0.024673 |
| C3 | DEG_AD_up | 43 | 3.043278 | 0.01705 | 0.328593 | 0 | 0.042101 |
| SEL1L | DEG_AD_up | 42 | 3.036065 | 0.013066 | 0.329374 | 0 | 0.045635 |
| DSG1 | DEG_AD_down | 41 | 3.046163 | 0.00857 | 0.328282 | 0 | 0.068464 |
| GJA1 | DEG_AD_down | 41 | 3.035199 | 0.015703 | 0.329468 | 0 | 0.04037 |
| MEF2C | DEG_AD_up | 41 | 3.039238 | 0.008676 | 0.32903 | 0 | 0.068892 |
| LYZ | DEG_AD_up | 40 | 3.042123 | 0.008578 | 0.328718 | 0 | 0.065086 |
| GSTO1 | DEG_AD_up | 38 | 2.820254 | 0.010905 | 0.354578 | 0.019915 | 0.030356 |