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Schematic representation of the renin-angiotensin system (RAS). Activation of AT2-r and MasR receptors induce vasodilatory, anti-inflammatory, and antifibrotic effects with potential clinical benefit in the most severe stages of SARS-CoV-2 infection, in contrast, vasoconstrictor, proinflammatory, and profibrotic effects mediated by AT1-r activation could increase lung and tissue damage
