Extended Data Fig. 9. Identification of FOXO1 target genes by ChIP-seq.
a, Genome-wide analysis of FOXO1 binding peaks revealed the FOXO1 high-affinity binding sequence as the most enriched motif in the immunoprecipitated chromatin of FOXO1A3-transduced HUVECs. b, Distribution of FOXO1 bindings peaks relative to the transcriptional start site (TSS), showing preferential binding of FOXO1 to genomic regions located at gene promoters near the TSS. c-f, ChIP-seq signals for FOXO1, H3K27Ac and H3K4me3 at the genomic loci of (c) OXCT1, (d) PDK1, (e) PDK4 and (f) MXI1. The FOXO consensus motifs that are bound by FOXO1 are highlighted in orange. ChIP-seq signals are represented as reads per kilobase million (RPKMs).