. 2021 Jan 18;180(5):1593–1602. doi: 10.1007/s00431-020-03915-x

Table 4.

Transthoracic echocardiographic features in normal-weight, obesity, and severe obesity in childhood-onset, adamantinomatous craniopharyngioma recruited in HIT-Endo and KRANIOPHARYNGEOM 2000/2007. Depicted are means and ranges

TTE parameter		BMI SDS, n		p value
IVSd (mm), % abnormal value	4.6 (4.4–9.3), 8%	7.1 (4.9–12.0)^2md, 8%	9.7 (6–12.8)^4md, 44%	0.012, 0.015^#
LVIDd (mm), % abnormal value	48.6 (33.4–58.6), 8%	53.1 (35.6–59.5)^2md, 14%	46.2 (36.0–59.1)^3md, 44%	0.161, 0.057^#
LVPWd (mm), % abnormal value	5.3 (3.9–9.4), 0%	5.8 (4.2–11.5)^2md, 8%	5.05 (4.5–11.8)^4md, 33%	0.323, 0.586^#
TAPSE, % abnormal value	22.5 (15.8–28.8)^5md8%	25.6 (17.0–28.3)^8md, 0%	25.8 (22.2–34.3)^3md, 0%	0.356, 0.189^#
EF (%), % abnormal value	68.0 (59–71), 0%	66.5 (62–74)^2md, 0%	67.5 (64–74)^4md, 0%	0.064, 0.020^#
FS (%) % abnormal value	38.0 (30–40), 0%	36.5 (33–41)^2md, 0%	37.0 (33–43)^3md, 0%	0.148, 0.056^#

TTE parameter

BMI SDS, n

p value

Normal weight, 13 (BMI − 2 to + 2 SDS)

Obesity, 14 (BMI + 2 to + 8 SDS)

Severe obesity, 9 (BMI > + 8 SDS)

IVSd (mm),

% abnormal value

4.6 (4.4–9.3),

7.1 (4.9–12.0)^2md,

9.7 (6–12.8)^4md,

44%

0.012, 0.015^#

LVIDd (mm),

% abnormal value

48.6 (33.4–58.6),

53.1 (35.6–59.5)^2md,

14%

46.2 (36.0–59.1)^3md,

44%

0.161, 0.057^#

LVPWd (mm),

% abnormal value

5.3 (3.9–9.4),

5.8 (4.2–11.5)^2md,

5.05 (4.5–11.8)^4md,

33%

0.323, 0.586^#

TAPSE,

% abnormal value

22.5 (15.8–28.8)^5md8%

25.6 (17.0–28.3)^8md,

25.8 (22.2–34.3)^3md,

0.356, 0.189^#

EF (%),

% abnormal value

68.0 (59–71),

66.5 (62–74)^2md,

67.5 (64–74)^4md,

0.064, 0.020^#

FS (%)

% abnormal value

38.0 (30–40),

36.5 (33–41)^2md,

37.0 (33–43)^3md,

0.148, 0.056^#

md, missing data; BMI, body mass index; EF, ejection fraction; FS, fractional shortening; IVSd, interventricular septal thickness in diastole; LVIDd, left ventricular internal diameter in diastole; LVPWd, left ventricular diastolic posterior wall thickness in diastole; TAPSE, tricuspid annular plane systolic excursion; SD, standard deviation; TTE, transthoracic echocardiography

^#p value of difference between the normal weight (BMI ≤ + 2 SDS) and the obese (BMI SDS > + 2 SDS) group